| Objective: This study aims to evaluate the potential relationship between liver function and AD by analyzing the relationship between liver function of human peripheral blood and the level of Aβ1-42,cognitive function.Methods: The subjects 47 patients with AD(observation group)who were clearly diagnosed in Guizhou Province from September 2018 to April 2020.According to the similar age,same gender composition and matching educational level,47 cases of normal population(Control group)were collected from the physical examination department of the Affiliated Hospital of Zunyi Medical University,they are middle-aged and elderly over 50 years old.Clinical data of the two groups of patients are collecting,such as age,gender,height,weight,education level,Marital status,residential area,family structure,previous smoking,drinking history,whether there are other causes of cognitive dysfunction(such as cerebral infarction,cerebral hemorrhage,etc.),and whether there are other causes of liver damage(Such as primary liver cancer,virus hepatitis,Drug-induced liver injury,influence of external toxicants,etc.),whether there are metabolic diseases such as hypertension,diabetes,etc.,and The serum liver function and Aβ1-42 of 94 middle-aged and elderly patients were detected by spectrophotometry and double antibody sandwich enzyme-linked immunosorbent assay(ELISA).Liver function mainly includes alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(total bilirubin,TBil)and direct bilirubin(DBil),Indirect bilirubin(IBil);Mini-Mental State Examination(MMSE)was used to evaluate the cognitive ability of middle-aged and elderly people.Results: A total of 94 study subjects were included in this article.The average age of the observation group was 77.34 ± 8.17 years,and the average age of the control group was 74.43 ± 8.01 years.There were no statistically significant difference in gender,education level,marital status,residential area,family structure,age and BMI(P>0.05).ALT,AST,DBi L(26.74±15.487U/L,30.13±10.964U/L,3.66±1.856μmol/L)in the observation group compared with the control group(19.62±13.310U/L,20.77±7.973U/L,2.80±1.024μmol/L)were increased;the level of Aβ1-42 in the observation group(0.60±0.368pg/μL)was higher than the control group(0.36±0.601 pg/μL);the score of MMSE in the observation group(14.47±3.688points)was lower than the control group(25.85±0.465),and the differences were statistically significant(P<0.05).The Pearson correlation analysis showed that ALT was positively correlated with Aβ1-42(r=0.235,P=0.023);AST and DBiL were all negatively correlated with score of MMSE(r=-0.435,P=0.000;r=-0.275,P=0.007).with the Serum level of Aβ1-42 and scores of MMSE as dependent variables,the effects of age and family were corrected(P<0.1),and Multiple linear regression showed that ALT was positively correlated with the level of Aβ1-42,β(95%CI)=0.010(0.000,0.020),P=0.043;AST and TBiL were negatively correlated with total score of MMSE,β=(95%CI)=-0.254(-0.395,-0.112),P=0.001,β(95%CI)=-1.398(-02.262,-0.543),P=0.002;Among the various cognitive function scores,AST has no obvious correlation with memory,and is negatively correlated with other cognitive functions;TBiL was negatively correlated with scores of cognitive function,and all have statistics Significance;and VIF<5 were among the above respective variables,there were no obvious collinearity.Conclusion: Impairment of liver function is related to the serum level of Aβ1-42,and is related to cognitive function;People with impaired liver function are a high-risk population of AD and a key population for health management of general practitioners. |
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