Clinical Retrospective Analysis Of 330 Cases Of Henoch-Sch?nlein Purpura

Objective: Research the general information,clinical features and laboratory examination of patients with Henoch-Sch?nlein Purpura(HSP).The risk factors of HSP with renal involvement and gastrointestinal tract involvement were analyzed,which provided evidence-based basis for clinical diagnosis and treatment.Methods: The data of 330 in patients diagnosed with HSP in dermatology department of our hospital from January 2018 to December 2020 were collected.Grouping: 1.They were divided into juvenile group(<14 years old)and adult group(≥14 years old)by age;2.According to clinical symptoms,they were divided into simple type,abdominal type,renal type,joint type and mixed type;3.According to the renal and gastrointestinal involvement,the patients were divided into the group with or without renal involvement and with or without gastrointestinal involvement.Results: 1.A total of 330 patients were collected,containing 222 cases in the minor group and 108 cases in the adult group,in the proportion 2.06:1.There were significant differences in clinical types and course of disease between the two groups(P<0.05).The joint type is common in minors,while the kidney type and mixed type are common in adults.The course of disease and hospitalization days of the adult group were longer than those of the minor group,and the hospitalization expenses were higher.There were 164 males and 166 females.The ratio of male to female was 0.99:1.2.There were 65 cases first appeared in spring,46 cases in summer,95 cases in autumn and 124 cases in winter.3.There were 229 cases with definite predisposing factors,including 170 cases of respiratory tract infection(51.52%).4.There were86 cases of joint type,80 cases of mixed type,79 cases of simple type,44 cases of renal type and 41 cases of abdominal type.5.This study showed that there were significant differences in white blood cell count(WBC),neutrophil granulocyte count(NE),c-reaction protein(CRP),d-dimer(D-D),creatine kinase(CK),creatine kinase isoenzymes(CK-MB)and procaicltonin(PCT)between the two groups with and without gastrointestinal damage(P<0.05),while there were significant differences in platelet count(PLT),Immunoglobulin E(Ig E),albumin(ALB),immunoglobulin A(Ig A)and age between the two groups with and without renal damage(P<0.05).Logistic regression analysis showed that D-D was independently associated with HSP complicated with gastrointestinal damage(P<0.05),age and PLT were independently associated with renal damage(P<0.05).Conclusions: 1.HSP is common in minors,the highest incidence is 7～13 years old,the incidence rate of male and female is 0.99:1.2.The course of disease in the adult group is longer than that in the minor group,and renal damage is more likely to occur.3.HSP often occurs in autumn and winter,and respiratory tract infection is the primary pathogenic factor.4.D-D is an independent risk factor of HSP with gastrointestinal damage.5.Age and PLT are independent risk factors of HSP with renal damage.