Correlation Between Systemic Immune Index And Prognosis Of Hepatocellular Carcinoma After Operation

Objective:To investigate Correlation between the systemic immune inflammation index and prognosis after hepatocellular carcinoma resection.Methods:Analysis of Clinical data of HCC patients in Taihe Hospital affiliated to Hubei Medical College,calculate the SII value,make the ROC curve,determine the boundary value,patient were divided into two groups :low SII and high SII.Analysis of differences between two groups of basic data using the chi-square test or test.Applying K-M Method to Survival Curve and analysis of differences between the two groups.Analysis of single and multivariate factor using Cox regression proportional risk model.Results:The AUC calculated by ROC curve was 0.84(95% CI:0.765-0.901),The Jordan index has a maximum of 0.619,SII optimal threshold is 293.45,The sensitivity and specificity were 75.3%;86.6%.Patients were divided into low sii group(SII≤293.45)and high SII group(SII>293.45),There were 78 cases and 70 cases,respectively.K-M analysis results: recurrence rate and survival rate of patients 1-2-year were31.2%,48.6% and 91.6%,73.9%,the recurrence rate of low SII patients and high SII patients 1-2-year were 21.4%、37.2% and 42.1%、61.4%,the survival rate of low SII patients and high SII patients 1-2-year were 91.8%、83.6% and 90.4%、64.5%,the recurrence and survival rate of HCC patients in low SII group was better,the difference between the two groups was statistically significant.Univariate analysis showed that SII level,AFP level,BCLC stage,tumor size,margin,MVI grade were risk factors for tumor recurrence and survival.COX multivariate survival analysis showed that MVI grade,SII level and BCLC stage were independent risk factors for postoperative tumor recurrence and survival time in patients with liver cancer(p<0.05).Conclusion:The high preoperative SII may be an independent risk factor for early tumor recurrence and poor prognosis in HCC patients,the high SII level indicates a poor prognosis.