A Comparative Study Of Motor Symptoms And Motor Complications In Pain And Non-pain Patients With Parkinson’s Disease

Objective:To compare the differences of motor symptoms and motor complications between pain and non-pain patients with Parkinson’s disease(PD),and analyze the relationship with PD pain.Methods:The study recruited 20 healthy controls(HC)and 47 patients with PD,who admitted to the First Hospital of Shanxi Medical University outpatient service of PD from January2019 to December 2019.According to the total score of King’s Parkinson’s disease pain scale(KPPS),26 patients with PD were included into pain group and 21 patients were enrolled into non-pain group.Then using the Parkinson’s Kineti Graph(PKG)was used to objectively assess the motor symptoms,such as Bradykinesia Score(BKS)and Percent Time with Tremor(PTT),and motor complications,such as Dyskinesia Score(DKS)and Fluctuation Score(FS).Then we analyzed the differences of quantitative scores of motor symptoms and motor complications among the groups,and the correlation between the total pain score and clinical characteristics of PD patients,and explored the relationship between the scores of each pain subtype and FS in pain group.Results:Compared with the control group,BKS and PTT were higher in pain group and non-pain group(P<0.05).Compared with the non-pain group,FS was higher in the pain group(P<0.05).Correlation analyse found that the total KPPS pain score of PD patients was negatively correlated with the onset age(r=-0.410,P < 0.01),and positively correlated with the course of disease(r=0.505,P < 0.01),levodopa equivalent daily dose(LEDD)(r=0.460,P<0.01),and FS(r=0.662,P<0.01).FS was positively correlated with fluctuation-related pain(r=0.578,P=0.002)and oral-facial pain(r=0.401,P=0.042)in the pain group.Conclusion:Pain and non-pain patients with PD show differences in motor fluctuation,but no significant differences in bradykinesia and tremor.The severity of pain in PD patients was related to the age of onset,course of disease,LEDD and motor fluctuation.The subtypes of PD pain associated with motor fluctuation are oral-facial pain and fluctuation-related pain.