Impact Of Preoperative Hormonal Stimulation On Postoperative Complications After Hypospadias Repair In Children:A Meta-analysis

Objective:To evaluate the effects of preoperative hormone therapy on the postoperative complication rates in children with hypospadias repair.Methods:Relevant randomized controlled trials published from the self-built database to June 2020 were retrived in the electronic databases of CNKI,WANFANG,PubMed,Embase and Web of science.The studies were screened according to the inclusion and exclusion criteria,the date were extracted and the quality was evaluated by 2 independnet reviewers.After that,the Meta-analysis was conducted using RevMan 5.4 Software.Results:A total of 6 studies were included,involving 641 cases.In comparison with placebo group,hormone group showed lower incidence rate in the postoperative urethrocutaneous fistula(OR=0.43,95%CI: 0.25～0.75,P<0.01)and reoperation(OR=0.35,95%CI: 0.20～0.60,P<0.01),but no significant difference in the incidence rate of meatal stenosis,urethral diverticulum and glanular dehiscence(P>0.05).Conclusion:Preoperative hormone therapy in children with hypospadias shows advantages of better intraoperative conditions,lower incidence rate of urine leakage and reoperation,and will not increase the incidence rate of other complications.