| Research Objective: This paper analyzes the clinical cases of Professor Wu Bingcai in the treatment of palpitation through data mining technology,and analyzes the syndrome differentiation and prescription rules of Chinese medical master Wu Bingcai in the treatment of palpitation,so as to provide reference for medicine use and dialectical thinking for TCM treatment of palpitation.Research Methods: Clinical cases of palpitation treated by Professor Wu Bingcai in the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from July 2016 to November 2020 were selected and collected as the original materials.The samples were included in strict accordance with the clinical diagnostic criteria for palpitation.Among them,260 cases(494 visits)met the criteria.All clinical data were recorded using Microsoft Office Excel 2007,and an electronic medical record database was established.Further data processing was carried out according to patients’ general conditions,medical symptoms,prescriptions and treatment methods,and drug names and TCM terms in medical records were standardized.The software SPSS Statistics 22,SPSS Modeler18 and GEPHI0.9.2 were used for frequency analysis,drug cluster analysis,drug association rule analysis and drug complex network analysis.Research Findings:1.A total of 260 complete medical cases of palpitation were collected,including 166 female patients,accounting for 63.8 percengt,and 94 male patients,accounting for 36.2 percent.The ages of the patients included ranged from 7 years in the youngest patient to 90 years in the oldest.In terms of age distribution,the frequency of palpitations in patients aged between 40 and 59 was higher,accounting for 27.73 percengt.Female patients aged between 40 and 59 accounted for 58.43 percent of all age groups,twice as many as other age groups.2.Frequency Analysis: The most common symptoms were central palpitations,followed by chest tightness,fatigue,thirst,poor sleep,dizziness,spontaneous sweating,chills,bitter mouth,irritability,greasy mouth and red throat.The highest frequency of tongue image is red tongue,dark tongue,yellow and greasy moss,etc.Pulse frequency is the highest for cun wang,cun floating,soft pulse,thin pulse string,pulse string.The drug frequency statistics showed that licorice,poria cocos,tangerine peel,angelica,ginger,bupleurum,Pinellia tuber,white paeoniae root,Chinese jujube,Dangshen,Radix Polygoni Radix,Atractylodes macrocephala were used more times.The core drugs were classified into drug types,among which the most frequent drug types were antipyretic drugs,followed by deficiency tonic drugs and antipyretic drugs.3.Analysis of Association Rules: By analyzing the drugs in 494 TCM prescriptions,commonly used drugs have Chenpi-Zhu Ru,Honeysuckle-Mab,Arctium lappa-Mab,Forsythia forsythia-shot dry,Angelica-Atractylodes Rhizoma,Eucommia-Mistletoe.Commonly used medicine group has Chen Pei-Zhu Ru-Fa Pinellia.The drugs with the highest correlation with chest tightness and panic are Tulip,Perilla Stem,Fragrant,Bitter almond,Licorice,Ophiopogon Japonicus,Platycodon grandiflorum,Fried Fructus Aurantii.4.Cluster analysis: among the 494 TCM prescriptions,the drugs with frequency ≥ 70 times were classified into 4 categories by cluster analysis.Cluster 1 included Marburi,Radix Artemisiae,Burdocks,Honeysuckle,Forsythia,Turmeric Turmeric,Loquat Leaves,Bitter Almond,Licorice,Fructus Fructus,Magnolia officinalis,Pinellia officinalis,Bamboo Rhizoma,Tangerine Peel,Fructus Aurantii and Fructus aurantii.Cluster 2 included Eucommia ulmoides,mistletoe,angelica,Atractylodes atractylodes,Divine Comedy,Atractylodes atractylodes,Astragalus membranaceus,Phellodendron phellodendron,Radix Ophiopogonis,Schisandra fruit,Alisma orientalis,Dangshen shen,Radix Puerariae and Salvia miltiorrhiza.Cluster 3 included Gardenia jasminoides,Mint,Bupleurum,Cortex Moutan,Paeonia lactiflora,Poria cocos,Anemarhizae Rhizoma,Ligusticum chuanxiong,Zizyphus jujube seed,and Rhizoctonia japonica.Cluster 4 scutellaria,cassia twigs,ginger,jujube,floating wheat,cooked licorice.Research Conclusions:1.According to the analysis of tongue,pulse,drug frequency distribution table and association,the main pathogenic factors of palpitation are dampness,heat,blood stasis and sputum.Professor Wu Bingcai carefully differentiated the symptoms of palpitation.The idea of syndrome differentiation was to examine Yin and Yang and pay attention to Qi and blood.The treatment from the five zang organs mainly focuses on the heart,liver and spleen.Pay attention to humidity,heat and blood stasis;By pulse and syndrome differentiation.2.In the treatment of palpitations,Professor Wu Bingcai paid attention to clearing dampness and heat first,and then to replenishing deficiency.3.From the analysis of drug association rules and drug cluster analysis,it can be concluded that the common drugs used by Professor Wu Bingchai in the treatment of palpation are: tangerine bark-bamboo shau,angelica sinensis-Atractylodes lancea,pericarpus pericarpus-sanguine stem,turmeric herb-loquat leaf and eucommia ulmoides-mistletoea.The core square has Yin Ma Wen Dandan soup,Dan Zhi Xiaoyao powder,Li Shi Qingshu Yiqi soup,Gan Mai Dazao soup,Suanzao Ren soup,Guizhi Glicorice soup. |