Clinical Observation Of Nalbuphine Combined With Propofol For Painless Colonoscopy In Children

Objective:To observe the effectiveness and safety of nalbuphine combined with propofol in children with painless colonoscopy.Methods:A total of 90 children aged 3 to 6 years old from the Children’s Hospital of Chongqing Medical University who underwent painless colonoscopy from May to October 2020 were randomly divided into 2 groups,45 cases in each group.Respectively:nalbuphine group（N group）:nalbuphine 0.3mg/kg intravenously combined with propofol3mg/kg;sufentanil group（S group）:sufentanil 0.2μg/kg intravenously combined with propofol 3mg/kg.According to the procedure of colonoscopy,observe the changes of HR,MAP,RR and Sp O2 of the two groups of children at immediately before administration（T₀）,3 minutes after administration（T₁）,when entering the endoscopy（T₂）,and after the spleen At each observation time point（T₃）,when the liver area is mirrored（T₄）,when polyp is removed（T₅）,when the lens is withdrawn（T₆）,and when the child opens his or her body movement（T₇）;recording induction time（IT）,examination time（total scan time,ST）,recovery time（RT）;observe analgesic effect（using BPS-NI score[Modified Behavioral Pain Scale score for non-intubated patients]>5 points and additional propofol assessment）and the incidence of adverse reactions.Results:There was no statistically significant difference in gender,age,body weight,ASA classification,operation type and number of polyps between the two groups（P>0.05）;HR,MAP,RR and Sp O₂of the two groups of children 3min after administration（T₁）were lower than immediately before administration（T₀）（P<0.05）;the respiratory rate and the oxygen saturation at T₁of the N group were higher than those of the S group（P<0.05）,and their recovery time was significantly shorter than that of the S group（P=0.00）;There was no significant difference in the analgesic effect between the two groups of children（P>0.05）;there were no adverse reactions in the N group,5 cases of coughing in the S group,and no serious complications occurred in the two groups.Conclusion:Nalbuphine combined with propofol has good sedative and analgesic effects in children’s painless colonoscopy,with little impact on breathing,low incidence of adverse reactions and quick recovery.