| ObjectiveThis paper is to evaluate the diagnostic value of long non-coding RNA(lnc RNA)in gastric cancer(GC)by meta analysis.MethodsPubMed,Web of Science,EMBASE,CNKI and Wanfang databases were retrieved.Literatures related to the use of lncRNA in the diagnosis of gastric cancer were collected,starting from the establishment of the database until April 1,2021.QUADAS-2 item tool was used to evaluate the quality of literature,Meta-Disc 1.4 and Stata 12.0 software were used for statistical analysis.Influence and univariate Meta-regression analyses were performed to trace the potential heterogeneity sources.Publication bias was judged by Deeks’ funnel plot asymmetry test.ResultsA total of 42 articles were included,including 4071 cases of gastric cancer and 3458 cases of non-cancer control.The SROC analysis manifested that lnc RNA test conferred a pooled sensitivity of 0.76(95%CI:0.75～0.77),specificity of 0.73(95% CI:0.72～0.74),positive likelihood ratio of 2.96(95% CI:2.59 ～ 3.39)and negative likelihood ratio of0.32(95% CI:0.28～0.37)in identification of GC,corresponding to an area under ROC curves(AUC)of 0.8289.Deeks’ funnel plot asymmetry test manifested no clear publication bias among studies.Conclusionlnc RNAs testing reveal promising diagnostic efficacy in the identification of GC and therefore might be popularized as auxiliary biomarkers for GC detection. |
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