| Background and Objective: Perihematomal Edema(PHE)is an important factor leading to poor prognosis in patients with intracerebral hemorrhage(ICH).However,up to now,there is still a lack of ideal imaging parameters related to perihematoma water as an indicator to evaluate PHE.In this study,the mean Hounsfield unite(HU)of PHE 72 hours after ICH was proposed to be used as a predictor of adverse clinical outcomes,and a retrospective controlled study was conducted to verify and analyze whether the mean HU of PHE 72 hours after ICH could be used as an independent factor in evaluating prognosis.Methods: Patients with ICH were included from tertiary medical institution.PHE was segmented by semi-automatic plane method to measure volume and mean HU.Outcomes of interest was poor 90-day prognosis(modified Rankin Scale score ≥ 3).Logistic regression was used to assess relationships with outcome.Results: A total of 159 patients with ICH were collected.The median mean HU of PHE at 72 hours was 22.1(IQR;19.2-25.0).Binary logistic regression showed that the72 hours PHE mean HU was negatively correlated with the poor prognosis of patients with ICH(OR;0.59;95% CI;0.47-0.75;P<0.05).The receiver operator curves(ROC)of meaningful indicators revealed that the area under the curve(AUC)of PHE mean HU at 72 hours was larger and the difference of AUC between PHE mean HU with PHE absolute volume or extension distance were statistically significant(p<0.05).The 72 hours PHE mean HU has higher value in predicting adverse prognosis of patients with ICH.Conclusion: The PHE mean HU at 72 hours was negatively correlated with the poor prognosis of patients with ICH.The prediction ability of PHE mean HU at 72 hours was better than PHE absolute volume and extension distance,contributing to a rather good index for predicting outcome of ICH. |
