A Study Of The Preparation And Properties Of PCL/ZnO-TCD Hernia Mesh

Hernia is a relatively common disease.How to repair the hernia and reduce the cross-infection rate during the repair process is one of the problems to be solved urgently in medical surgery.The traditional suture method has a high recurrence rate,and the implantation of non-degradable materials will have a certain negative impact on the patient’s body.The use of fully degradable materials to repair hernias is an inevitable trend in the future.This essay used pure water and absolute ethanol as solvents,trisodium citrate(TCD)as modifier,and nano-zinc oxide(ZnO)as raw material to prepare modified nano-zinc oxide(ZnO-TCD).Then,used polycaprolactone(PCL),ZnO-TCD as the experimental materials,and dichloromethane as the solvent,the PCL/ZnO-TCD composite mesh was prepared by 3D printing technology,And the effect of ZnO-TCD content on PCL/ZnO-TCD was further explored: The influence of performance parameters such as morphology,antibacterial property,degradability,rheology of the mesh.The research results showed that the prepared ZnO-TCD has a high-purity wurtzite structure,in the form of flakes and good dispersibility.With the increase of ZnO-TCD content,the hole shape of the mesh changed from square-like to ellipse,and then gradually changed back to square-like.The interaction between ZnO-TCD and PCL is just a simple physical blending,without destroying the molecular structure of PCL and generating new groups.The melting temperature and crystallization temperature of the PCL/ZnO-TCD composite mesh are positively correlated with the ZnO-TCD content.When the ZnO-TCD content is less than 7 %,the two changes little,but when the ZnO-TCD content reached 7 % and 9 %,the change range is obviously increased;the crystallinity change range of the composite mesh is similar,but the change trend is opposite.The thermal decomposition temperature of each component PCL/ZnO-TCD composite material is greater than280 ℃.With the increase of ZnO-TCD content,its thermal degradation temperature decreases slightly,and it can be molded at a higher temperature.However,the molding performance is worse than the PCL/ZnO-TCD composite material in the molten state.The PCL/ZnO-TCD composite molten slurry with a content of 5 % has the smallest viscosity and the best relative molding performance.When the content of ZnO-TCD is 5 %,the tensile performance of PCL/ZnO-TCD mesh is the best,and the pure PCL mesh is the worst.The ultimate tensile stress that can withstand is 22.8 N,which meets the standard of hernia(16 N);PCL and PCL/ZnO-TCD meshes with a composition of 1 % and 7 % require the least force to compress to a certain thickness and are relatively soft.The addition of ZnO-TCD has no obvious effect on the degradation rate of the PCL/ZnO-TCD composite mesh,and the contact angle of each component of the PCL/ZnO-TCD composite material has decreased.Among them,the composite mesh with a ZnO-TCD content of 5 % The tablets have the best hydrophilicity.PCL/ZnO-TCD composite mesh shows good antibacterial activity against Staphylococcus aureus(SA)and Escherichia coli(Ec).The antibacterial activity is better than PCL/ZnO composite mesh,and the antibacterial activity for Ec is better than SA.This shows that the mesh prepared in this paper can effectively reduce the infection problem during hernia surgery.