Effects Of Different Side-of-onset On Symptoms In Parkinson’s Disease

Objective: In most patients with Parkinson’s Disease(PD),motor symptoms usually start unilaterally.Despite the lateralization of brain function and the asymmetric damage of dopaminergic neurons,it is not clear whether different side-of-onset of PD will cause differences in symptoms.The sample size of the previous studies was very limited,and the conclusions were contradictory.This study aimed to evaluate the influence of different side-of-onset on the symptoms of PD.Methods: A total of 494 PD patients with left side-of-onset(LOPD)and 492 PD patients with side-of-onset(ROPD)were recruited in this study.Hoehn and Yahr(H-Y)scale and the third part of Unified Parkinson’s disease rating scale(UPDRS-III)were used to assess the patients’ motor symptoms.The assessment of Non-motor symptoms in Parkinson’s disease(NMSS),Mini-mental State Examination(MMSE),Montreal cognitive assessment(Mo CA),24-item Hamilton Rating Scale for Depression(HAMD-24),Parkinson’s Disease Questionnaire(PDQ-39),9-item Wearing-Off Questionnaire(WOQ-9),UPDRS-I,UPDRS-II,the REM behavior disorder screening questionnaire(RBDSQ),Parkinson’s disease sleep scale revised version(PDSS-2),the Sniffin’ Sticks 12-identification test(SS-12)were used to assess the patients’ non-motor symptoms.Compare the differences between the two groups of clinical data,motor symptoms and non-motor symptoms.Results: There were no significant differences in the clinical features,motor symptoms and non-motor symptoms between LOPD and ROPD(All P>0.05).Conclusions: The different side-of-onset has no effect on symptoms of PD.Same treatment and intervention can be taken for different side-of-onset PD patients.