Analysis Of Clinical Characteristics And Early Risk Factors Of Pulmonary Lesions Complicated By Paraquat Poisoning In 23 Children

Objective: To explore the early clinical characteristics and risk factors of children with paraquat poisoning complicated with pulmonary lesions,and to provide some reference for the diagnosis and treatment level and prognosis evaluation of children with paraquat poisoning.Methods: Retrospective analysis clinical data and early laboratory examinations of 23 children with paraquat poisoning who were treated and diagnosed in The Children’s Hospital In Hebei Province from January 2019 to September 2011.On the basis of the pulmonary imaging findings,the children were divided into groups with and without pulmonary lesions.Analysis the two groups of the epidemiology of pulmonary disease,laboratory examination results and risk factors affecting pulmonary disease.To provide some reference for the diagnosis,theatment and early prognosis evaluation of paraquat poisoning in children.Results: Among the 23 cases,9 cases were with the pulmonary lesion,9cases were without.The incidence of pulmonary lesions was 39.13%,Lesions mainly occurred in the early stage of intoxication(less than 7 days),and the exudative lesions were the main ones.It showed patchy high density shadow,ground glass high density shadow and consolidation shadow.There were significant differences in serum drug concentration,pediatric critical case score,p H value of blood gas,serum creatinine and fibrinogen concentration between the pulmonary disease group and the non-pulmonary disease group at admission(P< 0.05).Logistic regression analysis showed that serum drug concentration,pediatric critical case score,serum creatinine and fibrinogen concentration were independent risk factors for early prognosis evaluation of paraquat poisoning(P<0.05).Lasso multi-factor screening results indicate that the blood drug concentration is most closely associated with the occurrence of children with lung lesions(OR=9.86,95% CI: 1.10-88.72,P < 0.05),blood drug concentration are the major factors.Conclusions:1.Among the 23 children,9 cases with the pulmonary lesion,14 cases without the pulmonary lesion,and the incidence of pulmonary lesions was39.13%.The lesions mainly occurred in the early stage of poisoning(less than7 days),and the exudative lesions were the dominant lesions.2.This study showed that blood drug concentration,pediatric critical case score,serum creatinine and fibrinogen concentration at the early stage of hospitalization were independent risk factors for the occurrence of pulmonary lesions caused by paraquat poisoning,which could provide certain reference for the diagnosis and treatment level and prognosis evaluation of children with paraquat poisoning.Many factors work together,the blood drug concentration is the most important factor.