Analysis Of Serum Creatinine Level In Patients With Amyotrophic Lateral Sclerosis At Diagnosis

Objective: To investigate the level of serum creatinine(SCr)and it’s correlation with disease severity and progression rate in newly diagnosed amyotrophic lateral sclerosis(ALS)patients.Methods: The cases consisted of 77 ALS patients who were firstly admitted to the department of neurology,the second hospital of Hebei Medical University from June,2016 to September,2020.Correspondingly,165 healthy people at the physical examination center served as a control group.The basic information,disease information and SCr in ALSand health group were collected for farther analysis.Meanwhile,the severity was assessed by using ALS functional rating scale revised(ALSFRS-R).We analyzed SCr level of different subgroups and its correlation with ALSFRS-R score.Statistical analysis and description were performed with SPSS21.0.Results: 1.Analysis of ALS group and control group: the SCr level in ALS group was lower than that in the control group(P<0.05).2.Analysis of different ALS subgroups and control groups: the SCr levels in different sex,ages,onset sites,durations and dysphagia or not groups were lower than that in the control group(P<0.05).3.Analysis of different subgroups in ALS :Men have higher SCr levels than women(P<0.05),while there were no significant differences in SCr levels among different age groups,onset sites,durations and groups with or without dysphagia(P>0.05).4.Multivariate Logistic regression analysis: women(OR=0.043,95%CI:0.014-0.134),BMI(OR=0.863,95%CI:0.757-0.984)and SCr(OR=0.835,95%CI:0.797-0.876)were protective factors for ALS.5.Correlation analysis: there was no correlation between SCr level and BMI level after adjusting for gender(r=0.108,P=0.353).SCr level was positively correlated with ALSFRS-R score(r=0.328,P= 0.005),but not correlated with disease progression rate(r=-0.159,P=0.185)after adjusting for confounding factor.Conclusions: The SCr level of ALS patients at diagnosis was lower than that of control group,which was significantly positively correlated with ALSFRS-R score.SCr may be an important marker for monitoring the severity of ALS disease.