Photodynamic Therapy Combined With Supramolecular Salicylic Acid In The Treatment Of Moderate To Severe Acne

Objective To investigate the therapeutic effect of aminolevulinic acid-photodynamic therapy combined with 30% supramolecular salicylic acid in the treatment of moderate and severe acne.Methods Eighty patients with moderate and severe acne diagnosed in the dermatology clinic of Ning Xia Medical University General Hospital from September 2018 to August 2020,the age range is between 16 and 35 years old.regardless of sex,were randomly assigned to two groups with 40 patients in each group(n=40).Photodynamic therapy group: only Ella-photodynamic therapy was given at an interval of 2 weeks,2～4 times of photodynamic therapy as one course of treatment.Photodynamic therapy was terminated after the lesions such as papules,pustules and cysts basically subsided.Photodynamic combined with 30%supramolecular salicylic acid group: also given Ella-photodynamic therapy once every 2weeks,2～4 times as a course of treatment,papules,pustules,cysts basically disappeared,treated with 30% supramolecular salicylic acid,once every 2 weeks,a total of 4 times.After treatment,patients in both groups were treated with functional skin care products to repair skin barrier and maintain skin.The skin lesions of papules,pustules and cysts in the two groups were recorded before photodynamic therapy and 2,4,6 and 8 weeks after photodynamic therapy,respectively.After the end of photodynamic therapy,30% supramolecular salicylic acid was not given to the control group.The treatment group was treated with 30%supramolecular salicylic acid for 2,4,6 and 8 weeks after inflammatory erythema,pigmentation,scar and scar improvement.Results 1.Baseline data of patients: in the photodynamic combined with supramolecular salicylic acid treatment group: there were 40 patients,including 13 females(32.5%)and 27males(67.5%),with an average age of(21.43±4.48)years old.The photodynamic therapy group: a total of 40 patients,including 11 females(27.5%)and 29 males(72.5%),with an average age of(21.13±4.27)years old.Baseline data of moderate and severe acne patients between the two groups showed no conspicuous differences in gender and age(P>0.05).2.Evaluation of effective rate of skin lesions: there was no conspicuous difference in skin lesions such as papules and pustules between the control group and the treatment group(all P > 0.05).After 2 or 4 times of photodynamic therapy,the total effective rates of the control group and the treatment group were 80% and 85%,respectively.There was no conspicuous difference in the total effective rate between the treatment group and the control groupafter photodynamic therapy(P > 0.05).3.Comparison of the improvement of erythema,color sedimentation and scar after inflammation: after papules,pustules and cysts basically subsided,30% salicylic acid was not given to the control group,and 30% supramolecular salicylic acid was given to the treatment group.There was no statistical difference in erythema,color sedimentation,scar and cicatrix between the two groups before treatment with 30% salicylic acid(P > 0.05).After 4 times of30% supramolecular salicylic acid treatment,there was no statistical difference between the two groups(P>0.05).The improvement of erythema,pigmentation and scar after inflammation in the treatment group was significantly better than that in the control group without salicylic acid treatment(P < 0.05).Conclusion 1.Photodynamic therapy has a significant effect on severe skin lesions such as papules,pustules and cysts in patients with moderate and severe acne2.Photodynamic combined with 30% supramolecular salicylic acid can significantly improve erythema,pigmentation and scars in patients with moderate and severe acne.