Analysis Of The Efficacy Of TSH Suppression Therapy For Low-risk Papillary Thyroid Carcinoma

Objective: The postoperative TSH level of patients with papillary thyroid carcinoma was retrospectively analyzed to explore the influence of different TSH levels on recurrence.Methods:Liaoyang city central hospital general surgery were retrospectively analyzed from 2014 to 2016 in patients undergoing thyroid papillary carcinoma radical surgery(n= 486)were included in this study,all patients were performed after unilateral gland leaf total removal and isthmic portion excision plus lymph node in central region cleaning or total resection of thyroid + lymph node in central region,depending on the advantage of TSH throughout the follow-up period of 5 years,divided the patients into three groups(group A < 0.5 ～ 2.0,0.5,group B group C > 2.0 m IU/L),recurrence of known risk factors such as gender,age,tumor size and lymph node metastasis,The survival rate of recurrence was compared between the groups.Results:A total of 486 patients were enrolled in the study,with a male-to-female ratio of1:3.7.During the 5-year follow-up,there were 166(34.1%)patients in group A,with an average age of 49.41±10.74 years,sex(male/female)ratio of 37/129,average tumor size of 1.10±1.9cm,lymph node metastasis rate(no/no)of 128/38,and 4 patients with recurrence.Group B included 203(29.6%)patients,with an average age of 47.71±11.48 years,sex ratio(male/female)of 45/158,average tumor size of 1.19±2.6cm,lymph node metastasis ratio of 162/41,and 3 cases of recurrence.Group C included 117(36.3%)patients,with an average age of 49.67±10.58 years,sex ratio(male/female)of 21/96,average tumor size of 1.12 ±2.2cm,lymph node metastasis ratio of 98/19,and 3recurrence.The known risk factors for recurrence,such as gender,age,tumor size and lymph node metastasis,were analyzed by Log Rank test.The results showed that age P=0.123,gender P=0.153,tumor size P=0.08,lymph node metastasis P=0.184.KaplanMeier curve was drawn to compare the recurrence survival rate of the three groups,and P=0.755 was obtained.P value less than 0.05 was considered statistically significant.Conclusions:Different serum TSH levels have no effect on postoperative recurrence of low-risk papillary thyroid carcinoma at 5 years,and TSH inhibition should be treated individually.