Efficacy Of Chaishao Paishi Decoction In The Treatment Of Cholelithiasis

Objective:To investigate the effect and mechanism of chaishao Paishi decoction in treating cholelithiasis,and observe the differences in clinical effect of chaishao Paishi decoction combined with ursodeoxycholic acid capsules in the treatment of cholelithiasis before and after treatment.Method: In this study,100 cholelithiasis patients aged 16-60 years old in Zaozhuang Hospital of Traditional Chinese Medicine during the period from January 2020 to June2020 were selected(meeting the inclusion criteria).According to whether to take chaishao Paishi decoction or not,50 patients in the basic treatment group were selected on the random control.The basic treatment group only took ursodeoxycholic acid capsules(Ursofalk,250 mg/capsule),one capsule per time,three times a day;50 cases in the traditional Chinese medicine combined treatment group were selected.The traditional Chinese medicine combined treatment group took chaishao Paishi decoction on the basis of the treatment of the basic treatment group,one bag per time,twice a day.The total course of treatment was 3 months.Liver function,kidney function,blood lipid(cholesterol,triglyceride)and abdominal ultrasound(the size and number of calculi)of two groups were collected before and after treatment.And case withdrawals after the end of the course of treatment in the clinical study of traditional Chinese medicine combined treatment group and basic treatment group,and safety indicators,were recorded.Statistical software was used to analyze the clinical data.Results:(1)Comparison of general information: There was no significant difference in gender and age between the two groups.Two groups were comparable.(2)There was no significant difference in calculus size,triglyceride,total cholesterol and number of calculus between the traditional Chinese medicine combined treatment group and basic treatment group before treatment(P>0.05),showing that the illness severity before treatment was comparable.(3)After treatment,the calculus size,triglyceride,total cholesterol and the number of calculi in the combined treatment group were significantly improved compared with those in the basic treatment group,and the difference was statistically significant(P<0.05).(4)Efficacy evaluation: the total effectiveness rate of the traditional Chinese medicine combined treatment group was 76.0%,and that of the basic treatment group was52.0%.The statistical analysis of the total effectiveness rate between the two groups showed that there was a significant difference(P<0.05),and the total effectiveness rate of the basic treatment group was significantly lower than that of the traditional Chinese medicine combined treatment group.(5)In this study,gender,age,history of cholelithiasis,and diet were analyzed and compared.It was found that the total effectiveness rate of female patients with gallstone was higher than that of male patients,and the difference was statistically significant.The total effectiveness rate of young patients(16-40 years old)was higher than that of the elderly(40-60 years old)after treatment.The total effectiveness rate of patients with short history of cholelithiasis was significantly higher than that of patients with long history of cholelithiasis,but the difference was not statistically significant.The total effectiveness rate of patients with light diet and non-alcohol drinking was slightly higher than those with high fat diet and alcohol drinking,but there was no significant difference.(6)Safety comparison: There were no adverse reactions and drug toxicity in the two groups.Conclusion: Chaishao Paishi decoction combined with ursodeoxycholic acid capsules can significantly reduce the levels of cholesterol and triglyceride,the size of cholelithiasis and the number of calculi,with a total effectiveness rate of 76.0%,which is superior to the ursodeoxycholic acid capsule group,with obvious advantages,making it worthy to promote and apply it;according to the discussion of the factors for the improvement of the treatment effectiveness of patients with cholelithiasis,we conclude that female and young patients(16-40 years old)are the favorable factors for the improvement of cholelithiasis.