Relationship Between Perceived Dietary Salt Intake And The Risk Of Primary Liver Cancer

Objectives To explore the relationship between different salt intake habits and the risk of primary liver cancer.Methods Prospective cohort study was conducted.The data of the physical examination of employees of Kailuan Group in 11 hospitals including Kailuan general hospital from July 2006 to December 2018 were collected,including epidemiological survey content,anthropometric index and laboratory index.The data of perceived salt intake were obtained by questionnaire and divided into three groups:low salt diet group,medium salt diet group,high salt diet group.The outcome event was primary liver cancer,and the observation object with hepatocellular carcinoma or intrahepatic cholangiocarcinoma was defined as primary liver cancer.Through the Kailuan Group social security information system and the observation object’s medical records to obtain the data of primary liver cancer.We used Cox proportional regression model to analyze the relationship between perceived salt intake and the risk of primary liver cancer.The adjusted confounding factors included age,gender,body mass index,etc.In addition,we also stratified the high risk factors of primary liver cancer include HBs Ag positive,liver cirrhosis,fatty liver,etc,and repeated Cox proportional hazards model.Results During an average follow-up of（11.48±1.86）years,397 cases of primary liver cancer occurred.The total population incidence density of primary liver cancer was3.56/10000 person-years.The incidence density of low,medium and high salt intake groups was 2.33/10000 person-years,3.55/10000 person-years and 4.73/10000 person-years,respectively.The total population cumulative incidence rate of primary liver cancer was 4.50‰,while the cumulative incidence rate of low,medium and high salt intake group was 2.79‰,4.50‰,6.02‰,respectively.There were statistically significant differences in the cumulative incidence of primary liver cancer among the each group.(χ²=9.04,P_{log-rank test}<0.05).After adjusting for potential confounding factors,compared with the low salt intake group,the risk ratio and 95%confidence interval of primary liver cancer in the medium salt intake group and the high salt intake group were 1.49（0.97-2.29）and 1.98（1.22-3.22）,respectively(P_{for trend}<0.05).Conclusions High salt intake is an independent risk factor for primary liver cancer.Figure 3;Table 6;Reference 233...