Effects Of Repetitive Transcranial Magnetic Stimulation On Post-stroke Cognitive Impairment And Lipid Metabolism

Objectives To observe the effects of low-frequency repetitive transcranial magnetic stimulation(rTMS)on post-stroke cognitive impairment(PSCI)and lipid metabolism,and to provide reference for clinical rehabilitation.Methods From October 2019 to December 2020,80 PSCI patients who were hospitalized for rehabilitation in Shijiazhuang People’s Hospital and met the inclusion criteria were randomly divided into treatment group(n=40)and control group(n=40).Both groups of patients were given conventional medication,conventional rehabilitation training,and cognitive function training.The treatment group were given the contralateral dorsolateral prefrontal cortex(DLPFC)1Hz,90% motor threshold(MT)rTMS treatment,and the control group were given sham stimulation with the same stimulation parameters,20 minutes each time,once a day,5 days a week,continuous treatment for 4 weeks.Before the treatment and 4 weeks after the treatment,a rehabilitation therapist who did not participate in the treatment used Mini Mental State Examination(MMSE),Montreal Cognitive Assessment Mo CA and Modified Barthel Index(MBI)to assess the cognitive function and activities of daily living of the two groups of patients,and the blood lipids,thyroid hormone levels were detected.The collected data was entered and sorted using Excel2019,and SPSS25.0 statistical software package was used for statistical analysis,the measurement data were expressed as mean ± standard deviation,for normally distributed data,t test was used,which did not conform to normal distribution were tested by the nonparametric test,and the difference was statistically significant with P<0.05.Results 1 Comparison of cognitive function scores between the two groups of patients before and after treatment: there was no significant difference in the total scores of MMSE,Mo CA and the scores of each sub-item between the two groups before treatment(P>0.05);after 4 weeks of treatment: the total score of MMSE and the scores of each sub-item in the treatment group were higher than before treatment,and the difference was statistically significant(P<0.05);the total score of MMSE and the scores of orientation,recall ability,language ability in the control group were higher than before treatment,and the difference was statistically significant(P<0.05);the total score of MMSE and the scores of orientation,attention and calculation ability,language ability in the treatment group were higher than those in the control group,and the difference was statistically significant(P<0.05);after 4 weeks of treatment: the total score of Mo CA and the scores of each subitem in the treatment group were higher than before treatment,and the difference was statistically significant(P<0.05);the total score of Mo CA and the scores of language ability,delayed recall,orientation in the control group were higher than before treatment,the difference was statistically significant(P<0.05);the total score of Mo CA and the scores of attention,delayed recall in the treatment group were higher than those in the control group,and the difference was statistically significant(P<0.05).2 Comparison of MBI scores between the two groups of patients before and after treatment: there was no significant difference in MBI scores between the two groups before treatment(P>0.05);after 4 weeks of treatment: MBI scores of both groups were higher than before treatment,and the difference was statistically significant(P<0.05);the MBI score in the treatment group was higher than that in the control group,the difference was statistically significant(P<0.05).3 Comparison of blood lipids and thyroid hormone levels between the two groups of patients before and after treatment: there was no significant difference in blood lipids and thyroid hormone levels between the two groups before treatment(P>0.05);after4 weeks of treatment: the levels of serum total cholesterol(TCHO)and triglyceride(TG)in the treatment group was lower than before treatment,the difference was statistically significant(P<0.05);the levels of serum TCHO and TG in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05);after 4 weeks: the levels of serum triiodothyronine(T3)and thyroid-stimulating hormone(TSH)in the treatment group were higher than before treatment,the difference was statistically significant(P<0.05);the levels of serum T3 and TSH in the treatment group were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusions Low-frequency rTMS can improve the cognitive function and activities of daily living in patients with PSCI;and regulate lipid metabolism by increasing serum T3 and TSH levels,and reducing serum TCHO and TG levels.Figure 0;Table 10;Reference 160...