| Objective: Objective To observe the clinical efficacy of modified Longdan Xiegan Decoction in the treatment of young and middle-aged patients with primary hypertension of liver fire inflammation syndrome,and to explore the theoretical mechanism of blood pressure decline.Methods: From September 2019 to September 2020,a total of 75 patients in the second Department of Cardiology,Affiliated Hospital of Chengdu University of traditional Chinese medicine were collected.There were 38 males and 37 females.According to the random grouping method,they were divided into the control group and the experimental group.The control group was only given the hypertension patient education prescription,while the experimental group was given the self-made "modified Longdan Xiegan Decoction" on the basis of the patient education prescription.The course of treatment of the two groups was 4 weeks.The blood pressure drop,the improvement of clinical symptoms of traditional Chinese medicine and the changes of related auxiliary examination results of the two groups were observed,and the modified Longdan Xiegan decoction was statistically analyzed objective to observe the antihypertensive effect of decoction.Results: Before treatment,the basic data(gender,age,weight,body mass index,course of disease,blood pressure classification,etc.)of the experimental group and the control group were not statistically significant,indicating that the two groups were comparable.After treatment,the data analysis showed that the decrease of renin and daytime SBP load in the experimental group and the control group were almost the same,and there were no obvious adverse reactions and side effects.However,the effect of the experimental group was better than that of the control group in reducing diastolic blood pressure level,angiotensin Ⅱ level,weight,body mass index,clinical symptoms of traditional Chinese medicine,improving 24-hour blood pressure rhythm,and improving blood lipid(P<0.05). |
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