Analysis Of Clinical Features And Prognostic Factors Of Spinal Meningioma

Objective:Meningioma（SM）is a benign tumor originated from arachnoid cap cells or dural fibroblasts,Its incidence rate is second in spinal tumors,next to schwannoma.The prognosis of surgical resection is good,but as time goes on,some patients will relapse.The purpose of this study was to investigate the clinical characteristics of intraspinal meningioma and the factors associated with tumor recurrence.Methods:The study analyzed 82 patients with meningioma treated in the Department of neurooncology of the first hospital of Jilin University from January 2013 to December 2018,all of whom were pathologically confirmed as meningioma.Two patients died within 1 week and 1 year after operation,and 80 patients were finally included in the study.Clinical data extracted from samples included in the study,and the clinical data of patients were described and statistically analyzed.The obtained clinical data were entered into excel table in order and analyzed with IMB SPSS statistics 22.The preoperative and postoperative and long-term follow-up of neurological function were assessed by Mc Cormick clinical neural function classification.Results:Among the 80 cases,there were 10 males and 70 females,the proportion of male and female for 1:7.The maximum age is 81,the minimum age is 24,the median age is 0,and the average age is 0,There were 40 patients ≥ 60 years old and 40 patients < 60 years old respectively.Among the cases we studied,there were 37 cases of thoracic spinal meningioma,followed by 26 cases of cervical spine,only 2 cases of lumbar spinal meningioma,2 cases of cervical thoracic junction and 3 cases of thoracolumbar junction.Total resection（Simpson I-II resection）was performed in 71 cases and incomplete resection in 9 cases.Only one patient was WHO II tumor,and the rest were WHO I tumors.None of the postoperative patients underwent radiotherapy.The relative position of tumor and spinal cord was observed according to preoperative MRI,There were 31 cases of tumors located on the ventral or ventrolateral side of the spinal cord,and 49 cases located on the dorsal or dorsolateral side.There were 38 cases of tumors with more than two vertebral bodies（Including 2vertebral bodies）and 42 cases limited to one vertebral body.Before operation,70 patients with Mc Cormick I-II,10 patients had reached the level III to IV.Five patients mentioned recurrence during follow-up.Conclusion:Total tumor resection is the key factor affecting RFS of meningioma,Therefore,the primary treatment purpose of intraspinal meningioma is to achieve total tumor resection（Simpson I-II resection）.For meningiomas on the ventral side of the spinal cord,It is not the growth location of the tumor that is the factor leading to tumor recurrence,But the tumor growing there is difficult to operate,and it is difficult to achieve total resection of the tumor,resulting in tumor recurrence.To sum up,partial resection of tumor（Simpson III resection and above）is an important factor leading to tumor recurrence.