| Objective:In this study,the expression levels of fibrinogen-to-proalbumin ratio（FPR）and fibrinogen-albumin ratio（FAR）in the blood of colorectal cancer patients were analyzed,and their value in the auxiliary diagnosis of colorectal cancer patients was explored in conjunction with CEA and CA199Methods:From June 2019 to June 2021,100 cases of colorectal patients who came to our hospital for the first diagnosis and parallel surgical treatment were selected as the research group,133 cases of colorectal polyps patients who came to our hospital for treatment in the same period were selected as polyps groups,and 131 healthy patients who did not see abnormalities in the physical examination center were selected as the control group,and the general data of the sex and age of the three groups of patients were compared,and the difference was not statistically significant and can be compared.The levels of fibrinogen,albumin,prealbumin,CEA,CA199 in the serum of three groups of patients were detected,the values of FPR and FAR were calculated,the levels of FPR,FAR,CEA and CA199 in the serum of the comparative study group,polyp group and healthy control group were compared,and the data of FAR,FPR,CEA and CA199 were processed by Logistic regression analysis and the working characteristic curves（ROC curves）of subjects were plotted,and the FPR,FAR,and CA199 data were analyzed and compared.CEA and CA199 diagnose the sensitivity,specificity,truncation value and AUC of colorectal cancer,and combine the above indicators to plot the corresponding ROC curve to determine whether FPR,FAR combined with CEA or CA199 have advantages in improving the specificity and sensitivity of colorectal cancer diagnosis.According to the TNM staging system,100 patients with colorectal cancer were further divided into stages I-IV,and whether there were differences in serum fibrinogen,albumin,prealbumin,FPR and FAR in each stage were compared.Results:1.The expression of fibrinogen,FAR,FPR,CEA and CA199 was significantly higher than that of polyps and control groups（P<0.05）,the expression of albumin and pre-albumin in the study group was significantly lower than that of polyps and control groups（P<0.05）,and the expression of fibrinogen,FAR and FPR in polyps was significantly higher than that of control groups（P<0.05）.2.The sensitivity of FAR diagnosis of colorectal cancer by ROC curve was 82%,the specificity was 72.3%,the AUC was 0.821,and the 95%CI was 0.768 to 0.874.FPR diagnosed colorectal cancer ensitivity of 74%,specificity of 73.9%,AUC of 0.811,95% CI of 0.765 to 0.856.CEA diagnosed colorectal cancer sensitivity of 54%,specificity of 89.3%,AUC of 0.798,95%CI of 0.744 to 0.852.3.FPR joint CEA diagnosed colorectal cancer sensitivity of 87%,specificity of 81.4%,AUC of 0.892,95% CI of 0.857 to 0.926.FAR,FPR joint CEA diagnosed colorectal cancer sensitivity of 87%,specificity of 83.3%,AUC of 0.898,95%CI of 0.863 to 0.933.FAR,FPR joint CEA,CA199 diagnosed colorectal cancer sensitivity of 85%,specificity of 84.1%,AUC of 0.894,95% CI of 0.858 to 0.929.Conclusion:1.When FAR and FPR are diagnosed with colorectal cancer alone,the diagnostic efficacy is higher than that of the traditional tumor markers CEA and CA199,but the specificity is relatively low.2.The diagnostic efficacy of colorectal cancer after the combination of FAR,FPR,CEA and CA199 was improved compared with the diagnosis of each index alone.3.As an emerging,easily accessible and inexpensive inflammatory marker,FAR and FPR have certain diagnostic value in identifying benign and malignant tumors of the colorectum,which can provide an important reference for patients whether they need further confirmed tests. |
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