The Study Of Fibrinogen Combined With Total Bilirubin In Carotid Atherosclerosis Of T2DM Patients

Objective To explore the correlation between the occurrence of carotid atherosclerosis and fibrinogen and total bilirubin in patients with type 2diabetes mellitus and analyze the related risk factors for the occurrence of this disease,so as to provide basis for early identification and appropriate control of the occurrence and development of carotid atherosclerosis in type2 diabetes mellitus.Methods A total of 391 T2 DM patients treated in the First Affiliated Hospital of Dali University from September 2019 to October 2021 were randomly selected as type 2 diabetes mellitus group（T2DM group）.Them were divided into two groups based on whether carotid atherosclerosis occurred according to the results of Carotid color Doppler: T2 DM group including 126 T2 DM patients without complication（simple T2 DM group）and T2 DM combined CAS group containing 265 patients with type 2 diabetes mellitus complicated with carotid atherosclerosis（T2DM with CAS group）.Another 202non-diabetic patients who visited the hospital at the same time and matched in sex and age were selected as the control group.The general situation,complications and laboratory indicators of the above subjects were collected,and the data were statistically analyzed by SPSS 26.0 statistical software.Results1.Comparison between non-DM group and T2 DM group: The detection rates of BMI,smoking and CAS in T2 DM group were significantly higher than those in non-DM group,and the difference was statistically significant.（P <0.05）.2.Comparison of general data in T2 DM group: The SBP,BMI and smokingrate of T2 DM with CAS group were significantly higher than those in simple T2 DM group,and the difference was statistically significant.（P < 0.05）.3.Comparison of laboratory indexes in T2 DM group: The levels of FIB,TC and LDL-C in T2 DM with CAS group were significantly higher than those in simple T2 DM group,while the level of TBIL in T2 DM group was lower than that in simple T2 DM group,and the difference was statistically significant.（P < 0.05）.4.The ROC curve showed that the area under the curve of FIB and TBIL for predicting the occurrence of CAS in T2 DM patients was 0.70 and 0.68,respectively,the area under the curve of FIB combined with TBIL for predicting the occurrence of CAS in T2 DM patients was 0.75,with diagnostic sensitivity of 59.6% and specificity of81.0%.Compared with the single index of FIB and TBIL,the combination of the two has higher diagnostic efficacy in predicting the occurrence of CAS in T2 DM patients.5.Binary logistic regression analysis showed that smoking history,SBP,LDL-C and FIB were risk factors for CAS in patients with T2 DM,while higher level of TBIL within a certain range were protective factors for the development of CAS in patients with T2 DM.Conclusion1.Compared with the simple T2 DM group,the level of FIB in the T2 DM with CAS group was higher,while the TBIL level was lower.2.Compared with the single index of FIB and TBIL,the combination of the two has higher diagnostic efficacy in predicting the occurrence of CAS in T2 DM patients.3.FIB is an independent risk factor for CAS in T2 DM patients,while a higher level of TBIL within a certain range is a protective factor for CAS in T2 DM patients.