| Objective:By analyzing the clinical and laboratory data of 278 hospitalized children with Kawasaki Disease in our hospital,we can understand the differences in epidemiology,clinical manifestations and laboratory data between children with complete Kawasaki disease and incomplete Kawasaki Disease.And explored the risk factors of KD with Coronary artery lession,so as to identify high-risk children in time and improve the prognosis.Methods:Collected the information of children with KD,who were admitted to the Department of Pediatric Medicine of the First Affiliated Hospital of Dali University from2013 to 2021,and retrospectively analyzed for differences in age,gender,nationality,season,allergy history,total fever duration,maximum fever temperature,time and timing of IVIG,clinical manifestations,laboratory indices,and imaging changes.Meanwhile,the children were divided into Coronary artery lession（CAL）and Non-Coronary artery lession（NCAL）groups according to the Color Doppler echocardiography results.First,analyzed the Single-factor indices of clinic and laboratory data,and then the independent risk factors of CAL groups were selected using a multi-factor logistic regression analysis.Results:1.A total of 278 children with KD were admitted to our hospital,The median age of them was2.63,The age of onset was young.There were 159 boys（57.2%）and 119 girls（42.8%）,with a higher proportion of boys than girls and The male-female ratio was 1.33:1.KD was more prevalent in the summer.2.The differences between children in the c KD and i KD groups were statistically significant（P<0.05）in terms of age at onset,ethnic distribution,time and timing of IVIG,presence or absence of CAL,and presence or absence of anemia: compared with c KD group,i KD group demonstrated lower age of onset,lower proportion of Han Chinese children,lower incidence of CAL,longer start time for IVIG,higher rate of children who started IVIG for more than 10 days,higher incidence of combined anemia.3.The differences in the incidence of bilateral conjunctival congestion,lip and oral changes,rash,Extremity changes,cervical lymphadenopahty,and perianal skin changes between children in the c KD and i KD groups were statistically significant（P<0.05）: the incidence of typical clinical manifestations was higher in c KD group.4.There were no statistically significant differences between children in the c KD and i KD groups in terms of gender,total fever duration,maximum fever temperature,allergy history,season of onset,incidence of erythema of Bacillus Calmette-Guerin（BCG）scar,presence or absence of inflammatory changes on chest radiographs,presence or absence of mitral regurgitation,and presence or absence of pericardial effusion（P>0.05）.5.The differences in neutrophil,NLR,ALT,ALB,and CK-MB between children in the c KD and i KD groups were statistically significant（P<0.05）: compared with c KD group,i KD group had lower levels of neutrophil,NLR,and ALT,but higher levels of ALB and CK-MB.6.There were no statistically significant difference between children in the c KD group and children in the i KD group in terms of white blood cell,lymphocyte,Hb,PLT,MPV,PDW,CRP,ESR,and serum sodium concentration（P>0.05）.7.Statistically significant differences were found between children in the CAL and NCAL groups in terms of gender,age,allergy history,whether IVIG had been started for more than10 days,and type of Kawasaki disease（P<0.05）: compared with NCAL group,The CAL group had a higher proportion of males,a younger age of onset,a greater history of allergy,a greater proportion of children who had started IVIG for more than 10 days,and a lower proportion of children with i KD.8.There were no statistically significant differences between children in the CAL group and in the NCAL group in terms of total fever duration,maximum fever temperature,presence or absence of inflammatory changes on chest radiograph,presence or absence of mitral regurgitation,and presence or absence of pericardial effusion（P>0.05）.9.The differences in laboratory indicators between children in the CAL and NCAL groups were not statistically significant（P>0.05）.10.The results of multi-factor logistic regression analysis showed that allergy history（OR=2.359,95%CI:1.115~4.991）,IVIG initiation>10days（OR=3.198,95%CI:1.288~7.939）,diagnosis of c KD（OR=0.386,95%CI:0.196~0.759）were the independent risk factors for CAL.Conclusions:1.The onset age of KD in our hospital was young;the proportion was higher in boys;and the summer was the high incidence season,which need to be taken seriously.2.Compared with c KD group,children with i KD had a younger age of onset and were more likely to combine anemia.Compared with c KD group,i KD group had lower levels of neutrophil,NLR and ALT,but higher levels of ALB and CK-MB.3.Male,earlier onset age,allergy history,IVIG initiation >10 days,and diagnosis of c KD were correlated with CAL.allergy history,IVIG initiation >10 days,and diagnos is of c KD were the independent risk factors for CAL. |
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