Palladium-catalyzed Heck-type Cyclization Of Olefins In Series With Carbamoyl Chlorides To Construct Multifunctional Oxindoles

Oxindoles are the important heterocyclic structures,which are widely present in various natural products and biologically active molecules.Especially for 3,3-disubstituted oxindoles,which exhibit different biological activities.Therefore,it is of great significance to develop efficient synthetic methodologies to synthesize diversiform functionalized 3,3-disubstituted oxindoles.Compared with the method of direct functionalization of oxindole skeleton,the construction of 3,3-disubstituted oxindole moieties by domino Heck cyclization was recognized as a powerful tool and meanwhile diverse functional groups can be introduced by one step.In chapters 2 to 4 of this thesis,alkene-tethered carbamoyl chlorides were recognized as a type of useful starting materials for the construction of oxindole moieties,and a series of alkenylated,phosphorylated and silylated oxindoles were synthesized.These synthetic methodologies utilizing simple starting materials to synthesize target products bearing diverse functional groups under mild reaction conditions afforded a new strategy for the construction of diverse functionalized oxindoles.