Synthesis And Host-guest Properties Of Water-soluble Column[5]arenes And Biphenyl[n]arenes

The synthesis of macrocyclic compounds and the study of the host-guest properties are important components of supramolecular chemistry.By designing and synthesizing macrocyclic hosts and studying their host-guest chemistry,we can not only understand the host-guest interactions more deeply,but also discover new properties and functions,laying a foundation for further application such as assembly and identification.In this paper,the host-guest properties of water-soluble pillar[5]arene were deeply studied,and several new water-soluble macrocycles biphen[n]arenes were designed and synthesized.The details are as follows:In the second chapter,the host-guest interaction between water-soluble pillar[5]arene(CP5A)and anti-tumor drug busulfan was deeply explored.It is found that CP5A can bind well with the busulfan in aqueous solution,and the bonding constant reaches(1.07±0.10)×10⁴ M^-1.In addition,the busulfan can be effectively stabilized,hydrolysis can be inhibited and solubility in water can be enhanced by the binding intcraction of CP5A.In the third chapter,based on a series of biphen[n]arenes reported by our research group,water-soluble quaterphen[3]arenes and pentabiphen[3]arenes with large cavity were designed and synthesized,and the binding behavior of water-soluble quaterphen[3]arenes to guest sodium cholate and sodium deoxycholate was studied.In the fourth chapter,the biphen[n]arenes with the pyrene and the anthracene functional groups were designed and synthesized.