Directing Group-assisted Nickel-catalyzed Arylalkylation And Remote Hydroalkylation Of Alkenes

Transition metal-catalyzed functionalization of alkenes is an efficient method to rapidly construct complex molecules from inexpensive and readily available industrial feedstocks.For this reason,it is of great practical significance to explore the functionalization of olefin.The hydrocarbofunctionalization and dicarbofunctionalization of alkenes can rapidly construct new C-C bonds,providing an alternative and important synthetic method in contemporary synthetic organic chemistry fields.In this thesis,Ni-catalyzed arylalkylation and remote hydroalkylation of alkenyl amines are mainly investigated.This thesis consists of the following two sections:1.Nickel-catalyzed arylalkylation of homoallylamines.In this section,homoallylamine as the alkene substrate and quinolinamide as the directing group,arylalkylation and alkenylalkylation of homoallylamine has realized via redox neutral condition and the reduction condition,respectively.2.Nickel-catalyzed remote hydroalkylation of alkenylamines.In this section,alkenylamines as substrates,remote hydroalkylation of alkenylamines has realized by the assisting of directing group and the controlling by different ligands.By establishing these synthetic methods,carbofunctionalization products could be easily gained.The establishment of these synthetic methods provides a foundation and enriches the scope of substrates for the functionalization of alkenes.