Study On The Dynamic Mechanism Of L2/3 Pyramidal Neuronal XOR Function

Calcium-mediated action potentials(dCaAPs)generated by the apical dendrites of human layer 2/3(L2/3)pyramidal neurons have been suggested to contribute to XOR computational functions,yet the underlying physiological mechanisms affecting this specific function have not been fully investigated.To this end,in this paper,a simplified model of human L2/3 pyramidal neurons and a multi-compartment model of other mammalian L2/3 pyramidal neurons were constructed to investigate the effects of various factors on XOR function,with the following main results:First,a reduced model was obtained using the Neuron_Reduce method based on a detailed model of human L2/3 pyramidal neurons,thus reducing structural complexity and computational difficulty,which retains the main properties of human L2/3 pyramidal neurons.Here,we explored the effects of ion channels and capacitance contained in human L2/3 pyramidal neurons on apical dendritic XOR arithmetic functions.The results show that changes in conductance and capacitance do not directly disrupt XOR computational function in humans.Increases in gNa and Cm reduce the potential difference between dCaAPs under single versus dual pathway stimulation,thereby diminishing the salience of XOR function,but changes in gk have a weak effect on XOR computational function.Next,we constructed a multi-compartment model of L2/3 pyramidal neurons in monkeys,rats and mice,and added synaptic stimuli to the apical dendrites of their L2/3 pyramidal neurons separately to observe their firing patterns.The ratio of excitatory and inhibitory synaptic stimuli affects apical dendritic firing patterns.We modulated the ratio of 11 synaptic stimuli,but the apical dendrites of L2/3 pyramidal neurons in all three organisms failed to show XOR computational functions.It has been suggested that the XOR computational function produced by the apical dendrites of human L2/3 pyramidal neurons may be mediated mainly by the calcium currents that induce them to produce dCaAPs.To investigate whether this particular type of calcium current is the main factor responsible for the XOR arithmetic function of human L2/3 pyramidal neuron apical dendrites,we added this type of calcium current to human L2/3 pyramidal neurons.We added this type of calcium current to the apical dendrites of L2/3 pyramidal neurons of different species as described above.Simulation analysis revealed that the apical dendrites of L2/3 pyramidal neurons of all three species produced dCaAPs after the addition of this specific type of calcium current,and all of them could perform XOR arithmetic functions.In summary,the kinetic modeling and analysis of L2/3 pyramidal neurons of different species revealed that the calcium currents that induce the production of dCaAPs in the apical dendrites of human L2/3 pyramidal neurons are the key factors for the generation of XOR computations in neurons.Typically,the classification of linearly inseparable inputs generally requires complex neural networks for implementation.Classification of linearly inseparable inputs can also be achieved by the XOR function of a single pyramidal neuron.Therefore,the results of the theoretical analysis of the XOR function of pyramidal neurons in this thesis have important theoretical implications on how to induce the XOR function of neurons by experimental means and how to modulate the XOR function.