| The external environment has a significant impact on the dynamical behavior of living systems.For individual neurons,electrical,magnetic,light,sound signals,noise,and other external stimuli can cause changes in their firing patterns.For dual-organ systems,such as ears and eyes,these external stimuli can affect their synchronization properties.For cells,external stimuli can affect their self-replication,differentiation,and other functions.Therefore,studying the effects of the external environment on the dynamical behavior of living systems is one of the important topics in biophysics research.This paper focuses on the auditory neuron system and the cascade of cell phenotype transitions,studying the effects of sound signals,noise,and other factors on the dynamical behavior of the system.(1)Based on the Fitz Hugh Nagumo(FHN)neuron model,a single auditory neuron unit is constructed by embedding piezoelectric ceramics.By connecting two auditory neuron units through a coupling channel composed of a Josephson junction and a resistor in parallel,the human binaural neuron system is constructed.Introducing high and low frequency sound signals and noise signals,the effect of external factors on neuronal discharge mode and synchronization was studied by changing system parameters such as frequency and amplitude of sound signal,noise intensity,and so on.The results indicate that when there is no noise,the greater the coupling strength,the easier it is for the behavior of two auditory neurons to achieve synchronization;When the amplitude of low-frequency signals is changed,the discharge pattern of the two neurons will gradually change from rapid discharge to cluster discharge,but their synchronization characteristics are not affected;When the frequency of the signal is increased,the neurons will gradually shifted from cluster discharge to rapid discharge,and the current and voltage exhibit periodic oscillations.The synchronization characteristics are also not affected.When a noise signal is applied,increasing the noise intensity results in periodic oscillations of current and voltage,while the synchronization characteristics of the coupled neural circuit are not affected.This study is of great significance for studying the synchronization phenomenon between neurons and the processing methods of sound signals.(2)In bacterial communities,the presence of persistent cells increases the risk of recurrent infection.To address this issue,the noise characteristics of bacterial communities were studied from a stability perspective.The results indicate that when the stability factor reaches a certain threshold,the noises of normal cells and that of persistent cells will exchange with each other,making the noise of persistent cells much greater than that of normal cells.Persistent cells are almost completely eliminated by normal cells,and repeated infections are cured.In addition,the larger the value of the stability factor,the more stable the equilibrium state of the cell community,and the more significant the effect of treating recurrent infections.This study provides a theoretical solution for the treatment of recurrent infections in clinical practice. |
