| Remote monitoring of human health is vital in the field of biomedical applications.The aging problem is not only boosting the pressure of the national medical health-care system but also affecting people’s living quality.Currently,through reliable sensing technologies,it is possible to collect non-invasive biological fluids such as saliva,sweat,urine,and tears at home to monitor patients’ health conditions.This can effectively reduce the workload on hospitals and alleviate the pressure on the national healthcare system..Although the analysis of blood plays a key role in modern medical science,blood collection cannot be applied to wearable sensing devices because the invasive and harmful medical waste would be produced during the collecting process and it is necessary to complete the process with professional medical staff.Fortunately,people can trace their health conditions by monitoring biomarker concentrations in non-invasive biological fluids that are related to the concentration of certain biomarkers in the blood.The body fluids contain physiological biomarkers,such as ascorbic acid,uric acid,amino acids(such as tyrosine)and electrolytes(such as sodium,potassium and chloride).Among them,uric acid is an important biomarker of oxidative stress that will be produced due to athletes’ sports activities or ordinary people’s diseases such as chronic kidney disease;although tyrosine can improve people’s athletic ability,abnormal tyrosine concentrations are the danger signal of human bodies for metabolic disorders or liver diseases;ascorbic acid is a water-soluble vitamin which can promote the growth and physiological functions of human bodies.It can help to improve human bodies’ immune system,protect people from viral infections and prevent diseases such as nervous system diseases or even cancer.In conclusion,creating a wearable device that can quickly measure the nutritional status of the body is of great importance to strengthen the management of personal health conditions.(1)The flexibility of human fingers provides a good foundation for realizing integrated sensing technology and provides opportunities for the development of glove-based wearable sensors.In our research,a wearable glove sensor is constructed,which can detect uric acid in sweat,urine and saliva with high sensitivity and selectivity and transmit the data to the user interface wirelessly.We use carbon cloth as the sensing electrode and no additional modification of electrode material is required.Our sensor has high sensitivity,excellent stability and good anti-interference performance.In addition,we verified the accuracy of the system by performing practical experiments on samples provided by healthy human subjects and comparing the results with commercial kits.Our research has realized the detection of uric acid in multi-body fluids(sweat,urine and saliva),which is expected to be used in the area of disease-management(diseases such as gout).(2)Actively promoting the commercialization of Sweat-based wearable medical equipment has important practical significance for tracking health indicators and predicting diseases.Our study reports an example of the wearable skin sensor,which is fabricated by using screen printing technology.The wearable skin sensor is flexible and comfortable and can monitor uric acid,tyrosine and ascorbic acid in the sweat wirelessly and continuously.Besides,the sensor has a laser-etched multi-inlet microfluidic module which can be used for dynamic sweat sampling.In the study,we use the gold standard detection method to verify the accuracy of the system and perform practical application tests on samples provided by healthy human subjects.In addition,the concentration of uric acid in the sweat of patients with gout is evaluated before and after they take medicines.The comparison result shows that the sensor does have a certain potential to monitor gout. |
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