Three Type Of Substance Of Konjac Glucomannan As Carrier:Its Stability And Manageable Release Kinetics

In order to understand the structural characteristics and stability of KGM drug carrier,as well as the related properties and controlled release kinetics of the drug carrier,in order to provide some reference value for KGM as a drug carrier.This paper uses experimental method combined with molecular dynamics,KGM/SAA,KGM/CMC-Na,KGM/CMC-Na/SAA on the stability of drug carrier,related properties,and the controlled release kinetics of KGM/CMC-Na/SAA and KGM/SAA,to explore the relationship between different compound materials and stability,and the stability and release kinetics between law,for the further study of KGM as a drug carrier.To provide a theoretical basis for.The results of this study are as follows:a)In the vacuum state,the stability of three carriers,from strong to weak,are KGM/SAA,KGM/CMC-Na,KGM/CMC-Na/SAA;In the periodic boundary conditions,the stability of three carriers,from strong to weak,are KGM/SAA,KGM/CMC-Na,KGM/CMC-Na/SAA.According to energy,the enthalpy change of three carriers,from large to small,are KGM/CMC-Na/SAA,KGM/CMC-Na,KGM/SAA;Their potential energy,from large to small,are KGM/CMC-Na/SAA,KGM/CMC-Na,KGM/SAA.Therefore,the stability of three carriers,from strong to weak,are KGM/SAA,KGM/CMC-Na,KGM/CMC-Na/SAA.So,KGM/SAA may play a better synergistic effect.b)At 25℃,viscosity from high to low is KGM/SAA,KGM/CMC-Na,KGM/SAA/CMC-Na;Infrared spectra showed molecular bond strength,from strong to weak,is KGM/SAA,KGM/CMC-Na,KGM/SAA/CMC-Na.These are explained that the stability of three carriers,from strong to weak,is KGM/SAA,KGM/CMC-Na and KGM/SAA/CMC-Na;KGM/CMC-Na can not make a drug carrier by CaCl2 solution;The porosity of KGM/SAA drug carrier is high,73%;KGM/SAA/CMC-Na drug carrier with low porosity is 62.60%;KGM/SAA drug carrier particle size is about 0.51-0.58 mm,uniform distribution;KGM/SAA/CMC-Na drug carrier particle size is about 0.31-0.52 mm,the size distribution is not uniform;Electron microscopy showed that KGM/SAA drug carrier has larger porous,its surface looks smooth,shiny,with good toughness;KGM/SAA/CMC-Na drug carrier has smaller porous,and its surface looks more rough,tough,fragile.c)At 298.15 K,when stowage is saturation,stowage capacity of KGM/SAA drug carrier with 5-HT is 7 times higher than KGM/CMC-Na/SAA,the stowage quantity are 27 loading(640.17 mg·g-1)and 4 loading(94.84 mg·g-1);At 298.15 K,KGM/SAA with 5-HT,in 0.95?&1.11 ?,appears distinct layers,the peak are 11.61,19.94;The double weak peak are showed at 1.43 ?&1.51 ? or 2.07 A&2.15 A,their values are respectively 9.56&4.45 or 3.95&2.69.KGM/CMC-Na/SAA with 5-HT hierarchical position is roughly the same as hierarchical position of KGM/SAA with 5-HT,but the intensity of KGM/CMC-Na/SAA is weaker.The KGM/SAA performance in stowage has obvious advantages than KGM/CMC-Na/SAA;At 298.15 K,the diffusion coefficient of KGM/CMC-Na/SAA drug carrier is 6.03×10-10 m2·s-1,KGM/SAA is 1.54×10-9 m2·s-1.