Preparation Of MOF/Polymer And Its Application In Catalytic Degradation Of Nerve Gases And Cancer Treatment

Metal organic framework（MOF）is a type of nanoporous material composed of metal nodes and multi-position organic linking groups.It has the characteristics of large and permanent molecular porosity,ultra-high surface area and low density.It is widely used in gas storage and release,Drug delivery,catalysis and other fields.However,MOF itself has some shortcomings such as poor water stability,weak mechanical strength,and non-processability.In order to overcome these shortcomings of MOF in actual use and further improve its characteristics,the current main method is to combine MOF with various materials.UiO-66-NH₂ is coated with a layer of highly cross-linked polydivinylbenzene（PDVB）shell by using distillation precipitation method to form UiO-66-NH₂@PDVB composite material,in which the quality of PDVB accounts for about 25.6%.Then,in order to explore whether the modified material can improve the catalytic degradation ability,the two materials were applied in the nerve agent simulant degradation experiment.The experimental results showed that the modified UiO-66-NH₂@PDVB not only greatly improved UiO-66-NH₂’s own catalytic performance,also has high reusability,which is expected to be used in the degradation of nerve agents in complex environments.Mn-MOF nanoparticles with polyhedral shape and monodisperse size were prepared by solvothermal method mediated by acetic acid regulator,and PEG was grafted on the outer surface of Mn-MOF nanoparticles by conventional carbodiimide chemical method.When testing with pancreatic cancer cells in vitro and using an orthotopic pancreatic tumor model in vivo,it can be clearly observed that Mn-MOF@PEG has killing and therapeutic effects on cancer cells.This work is expected to greatly promote MOF in cancer immunotherapy in the future.In the application.