Tantalum Diboride Composite PEEK And Copper-Doped Biomaterials:Construction And Characterization

The good mechanical properties of PEEK and its elastic modulus matching with human cortical bone make it a promising application in the field of osteoarticular prosthetic implants.PEEK’s biocompatibility,antimicrobial properties,and friction and wear properties,on the other hand,need to be enhanced,which have an impact on the service life of prosthetic materials.In this thesis,TaB₂/PEEK composites were made by introducing TaB₂ nanoparticles into the PEEK matrix using a cathodic electrophoresis deposition technique,with the goal of improving the biocompatibility and tribological properties of PEEK.To improve the antibacterial properties of composites,copper elements were ion implantation onto the surface of composites to create composite antibacterial materials.（1）Electrophoretic deposition was used to create TaB₂/PEEK composites.On the structural and mechanical properties of composites,the impact of TaB₂ content and heat treatment temperature were evaluated.The results revealed that when the TaB₂ level was 3 wt%（PTB3）,the composite had the most homogeneous and dense morphology.The density and homogeneity of the composite were enhanced after heat treatment at 390°C,and the PTB3/390（3 wt%,390°C）thickness reached 160μm.The enhancing impact of TaB₂ particles on PEEK has a content-dependent extreme value;too little TaB₂ enhances the matrix continuity,while too much TaB₂cleaves it.The hardness of PTB3/390（212 MPa）is 15.56%higher than that of PTB0/390（179MPa）,which has the best mechanical qualities.（2）The friction and wear behavior of TaB₂/PEEK materials was investigated in two media:simulated body fluid（SBF）and fetal bovine serum（FBS）,and the in vitro cell proliferation ability and inflammatory response ability of the materials were evaluated using CCK-8,immunofluorescence staining and enzyme-linked immunosorbent assay（ELISA）.The lubricating effect of FBS is better,the material has a reduced friction factor and wear rate,and the PTB3/390wear rate was reduced 25.52%than that in SBF.The friction factor and wear rate of PTB3/390 in FBS medium were 0.119 and 1.08×10^-6 mm³·N^-1m^-1respectively,which decreased by 15.60%and69.05%compared with PTB0/390.In addition,PTB3/390 has a high biocompatibility,which can promote the secretion of M2 cytokines IL-10 and TGF-βand inhibit the expression of M1proinflammatory cytokines IL-1βand TNF-α.（3）Copper ions were introduced on the surface of PTB3/390 samples by ion implantation technique,and the surface morphology,phase structure,mechanical properties,tribological properties,antibacterial properties,and biocompatibility of the composite coatings in the FBS medium were evaluated.With the increase of injection dose of copper,the surface of the material showed undulating gullies,and the roughness and hydrophilicity were enhanced.Among them,the water contact angle of PTB3/390/6Cu(injection dose 6×10¹⁷ ions/cm²)was 16.28±2.95°,which was 77.07%lower than that of PTB3/390.The antibacterial properties and biological activity of the composite antibacterial materials were enhanced.After co-culture of PTB3/390/6Cu with Staphylococcus aureus and Escherichia coli for 24 hours,the antibacterial rates reached 99.66%and 99.86%,respectively.And the cell proliferation rate reached 120.88%when PTB3/390/6Cu samples were co-cultured with MC3T3-E1 cells for 5 days.