Preparation And Research Of Magnetic Controlled Drug Delivery Carrier Based On Fe₃O₄

Precision Medicine,a new medical technology which takes individual differences into account and designs individualized treatment plan,is a hot topic in the field of medicine research.However,how to deliver precise doses to specific parts of the disease at the desired time is still a research challenge.Magnetically controlled drug release,initiated by heat generated by magnetic nanoparticles driven by an alternating magnetic field,is a new form of external stimulus-responsive and non-invasive drug delivery.In this thesis,a magnetic controlled drug delivery system is designed,in which the drug release is initiated by the heat generated by magnetic materials driven by an alternating magnetic field,then,the precise release of the loaded drug is triggered by non-invasive alternating magnetic field to achieve the therapeutic effect of the disease.The main findings are as follows:(1)Chitosan magnetic nanoparticles were prepared with chitosan as surface modifier.Then,a novel drug delivery system was constructed using chitosan ferrosoferric oxide magnetic nanoparticles as carrier,thermal decomposition Azo compound as bridge,and toluidine blue as drug model molecule,the drug release of the carrier at different temperatures and under AMF driving was investigated.(2)Based on these studies,the delivery system of the antibacterial drug Vancomycin was successfully constructed.The drug release of the carrier at different temperatures and under AMF driving was investigated.Finally,the antibacterial activity and cytotoxicity of the drug delivery system were investigated in vitro.(3)A new hydrogel dressing based on polyvinyl alcohol and doped with the above mentioned carrier particles for Vancomycin drug delivery was successfully constructed.The drug release of the carrier at different temperatures and under AMF driving was investigated.Finally,the antibacterial activity and cytotoxicity of the drug delivery system were investigated in vitro.