Study Of The Behavior On The Assembly And Delivery Of Nanocarriers Based On Molecular Communication

Nanocarrier cell transport is a very promising medical technology.Different from the traditional drugs delivery mode,using nanocarriers can avoid the direct contact between drugs and normal cells of human body and protect normal cells from the toxic effects of drugs.It can reduce the demage of the human immune system to drugs and improve the utilization rate of drugs.It can even change the way some drugs are used,such as the oral use of insulin.Therefore,many studies use nanocarriers for targeted drugs delivery.However,due to many interference factors in human body environment,the proportion of targeted drugs reaching the target is still relatively low.In order to improve the proportion of targeted drugs reaching the target site,it is a good choice to construct a nanonetwork by using molecular communication technology to achieve targeted transport of nanocarriers.In this paper,based on the idea of molecular communication and dissipative particle dynamics,some processes of the assembly and transport of nanocarriers are simulated.This article combines the idea of molecular communication,defining the induced copolymer involved in assembly as the transmitter of the communication system,the assembled drugs as the receiver of the communication system,and the interaction between the induced copolymer and the assembled drugs as the signal of communication.The factors that may affect the communication process between the induced copolymer and the assembled drugs are studied from three aspects: the induced copolymer itself,the interaction between the induced copolymer and the assembled drugs,and the influence of the simulation system.The results of the communication are evaluated from the aspects of the success rate of the communication between the induced copolymer and the assembled drugs,the morphology and structure of the assembled micelle,and the size of the micelle.It is found that increasing the proportion of hydrophobic components in the induced copolymer,decreasing the interaction of hydrophilic components between the induced copolymer and the assembled drugs,increasing the interaction of hydrophobic components between the induced copolymer and the assembled drugs,and increasing the concentration of the induced copolymer and the assembled drugs in the system can promote the communication behavior between the nanocarriers and the assembled drugs.The delivery of nanocarriers in human body is also an indispensable step in the treatment of diseases by nanocarriers.In this paper,tumor cells are taken as the target cells.In order to improve the success rate and accuracy of communication between the nanocarriers and tumor cells,a kind of nanocarriers that can only ionize in acidic environment is designed according to the characteristics of low PH value of tumor tissues,and the factors that might promote the communication between the nanocarriers and tumor cells are studied.It is found that increasing the electric field interaction and the rigidity of the ligands on the surface of the nanocarriers can promote the communication behavior between the nanocarriers and tumor cells.In addition,the ionization ratio of the nanocarriers around the tumor tissue will also have a great impact on the communication behavior between the nanocarriers and tumor cells.When the ionization ratio of the nanocarriers is too high or too low,the communication behavior between the nanocarriers and tumor cells will be inhibited.The results can provide a new guidance for the actual design of nanocarriers.