Design And Construction Of Small Biomolecular Supermolecule Functional Materials

The supramolecular assembly based on biological small molecules plays an important role in the stability and function of biological structure.Inspired by the self-assembly structure of supermolecule in vivo,it has become an effective strategy to realize the rational design and development of new supermolecule functional materials by regulating the interaction of supermolecule between simple biological small molecules.In this paper,biological small molecule oligopeptides and amino acids are selected as models to explore the regulatory effect of metal ions on biological small molecule based supermolecule materials,and then a new type of supermolecule glass based on biological small molecules is constructed,which solves the problems of environmental pollution and poor biocompatibility of current glass materials.This article mainly includes the following content:Palmitoyl tripeptide-5（Pal-KVK）was dissolved in hydrochloric acid to form hydrogel through self-assembly of supermolecule.The adsorption of transition metal ions and rare earth ions on hydrogels was studied by means of ultraviolet visible spectrum and infrared spectrum.The data shows that Pal-KVK hydrogel can effectively adsorb metal ions,and its adsorption capacity for Co²⁺,Cu²⁺,Pr³⁺,Sm³⁺,Er³⁺is 284.51 mg/g,183.73mg/g,438.16 mg/g,665.34 mg/g,and 501.09 mg/g,respectively.SEM data showed that Pal-KVK hydrogel had a large structural transformation after adsorption of metal ions.The above results indicate that metal ions can produce strong interaction in the structure of small biomolecular supermolecule functional materials to regulate their structure.Based on the regulation of metal ions on small biomolecular supermolecule functional materials,methanol is further used as solvent in this paper,N-fluorene methoxycarbonyl-L-neneneba leucine（Fmoc-Leu-OH）,was mixed with the sulfate of transition metal ions Co²⁺,Cu²⁺,and Zn^2+,and then the solvent was volatilized,and the product was melt quenched to prepare an amino acid based glassy supermolecule functional material.By characterizing the products through fluorescence spectroscopy and nanoindentation analysis,it was found that the three samples introduced with metal ions have special fluorescence properties,and the Young’s modulus is as high as 5.8 Gpa,5.3Gpa,and 4.7 Gpa,respectively.The Vickers hardness is as high as 0.38 Gpa,0.31 Gpa,and 0.29 GPa,all of which are higher than that of organic glass.Based on the effective regulation of supermolecule interactions between small biomolecules,the above work designed and constructed small biomolecular based supermolecule functional materials.More importantly,the introduction of metal ions enables the controllable construction of biomolecular glasses with good biocompatibility and high mechanical strength.The supermolecule action of biomolecules can easily adapt to the integration of various functional modules,providing new ideas for the design and construction of functional materials.