A General Method For Selective Three-Component Carboacylation Of Alkenes Via Visible-light Dual Photoredox/Nickel Catalysis

The C-C bond is found in almost every complex chemical molecular structure,which plays an indispensable role in constructing the molecular skeleton and as an important substituent,and is of great significance for both the constitution of molecules and the chemical reactions of substances.Therefore,the search to construct C-C bond related reactions has also been the research direction of chemical workers cumminence.Over the past hundred years,numerous research findings have surfaced and applied to the ordinary life of the stepping person in all areas of biomedical chemistry.Researchers often used some noble metal catalysts,such as palladium,ruthenium,rhodium,and so on,in earlier C-C bond construction reactions.But gradually,such reactions are being discovered,with huge costs,complex reaction conditions,and difficulty in the postprocessing of experiments.Combined with the increasing emphasis on the environment by humans in recent years,green chemistry has gradually risen up.Therefore,it is urgent to find more efficient and environmentally friendly methods for the construction of C-C bonds in the new period.Visible light as a natural resource has its own natural advantages of low cost,large amount of resources,environmental protection and non pollution.Some chemical workers innovatively paired it with some cheap metals,synthesized many active molecules with huge effects,applied into related industrial fields such as biochemistry,and brought much convenience to human society.Ketones are ubiquitous building blocks in bioactive molecules,pharmaceuticals,and multipurpose intermediates in organic synthesis.Although transition metal catalyzed cross coupling methods have attracted significant attention for the construction of ketones,most of them are incompatible with electrophilic groups.Recently,nickel catalyzed intermolecular selective carbonylation of alkenes has emerged as an efficient protocol to form complex carbonyls by simultaneously installing two C-C bonds at the C-C double bond.Herein,we based on a visible light redox coupled with nickel synergistic catalytic strategy to achieve selective alkylacylation of alkenes as a target unfolding study,with alkenes with tertiary and secondary alkyl trifluoroborate esters and acyl chlorides as reaction substrates for the regioselective three component carbonyl acylation of alkenes via the cocatalysis of IR [DF(CF3)PPy] 2(bpy)PF6 visible photocatalyst with nickel.This redox neutral protocol enables the rapid construction of ketones with high complexity and diversity through a radical relay process.Mild conditions tolerate a number of functional groups,allowing a variety of commercially available mostly acyl chlorides,alkyl trifluoroborate salts,and olefins.