Research Of Optogenetic Neuromodulation System Based On Wireless Power Transmission

Wireless energy transmission is capable of transmitting energy in space using electromagnetic waves and sound waves as a medium.It is widely used in implantable medical research and clinical medicine due to its compact size and stable power transmission effect.Optogenetics is a neuroscientific research method that combines optics and genetics to genetically transcribe optoproteins into neuronal cells,giving them the ability to perceive light.Neuronal cells are able to be activated or inhibited by light stimulation.Compared to traditional neuromodulation modalities such as electrical and magnetic stimulation,optogenetic techniques are able to target and rapidly control neuronal cells and are important for the study of normal brain function and various brain diseases.The traditional wireless optogenetic neuromodulation experimental platform is complex and difficult to operate,which is not conducive to neurologists to focus on neurological research itself.In order to promote the development of neuroscience and help brain science research and application,this paper investigates the typical structure and development status of wireless implantable systems,compares the advantages and disadvantages of wireless energy transmission methods in different media,analyzes in detail the functional requirements and performance needs of neuronal modulation systems applied to small animals and human brains,and designs a complete,easy-to-use,and suitable for multiple scenarios wireless implantable multi-channel optogenetic neuromodulation experimental platform,the main work is as follows:First,this paper analyzes the coil resistance effect and skin effect of magnetic resonant wireless energy transmission,identifies the methods that can improve the transmission efficiency,analyzes the performance of the coil using self-inductance,quality factor,and scattering parameters,designs a flower-shaped planar in vitro electric energy transmitting coil,derives the calculation process of its self-inductance,and optimizes the design of the coil parameters according to the actual demand.Through finite element simulation for comparison and experimental verification,a metamaterial plane with nearly zero permeability is designed to shield electromagnetic waves and reduce magnetic leakage.Secondly,this paper analyzes the modeling of the high-frequency inverter circuit with a planar coil as the load,analyzes the theoretical performance of the inverter circuit based on the ideal circuit analysis method,designs a high-frequency power amplifier circuit based on the inverter circuit,and builds and fabricates the peripheral circuit with gallium nitride metal oxide transistors as the core components,tests and verifies its signal output performance,and simulates and verifies the feasibility of the cosymmetric system based on the inverter circuit for wireless energy transmission applications.Finally,this paper designed and fabricated a small size wireless multi-channel optogenetic implantable device,using a biocompatible package,and conducted remote photostimulation control tests in a simulated human tissue fluid environment,capable of remotely controlling the photostimulation probe on the implantable device within a range of8 meters,achieving flicker frequency adjustment within 100 Hz and independent control of red,green and blue light poles,finally building a complete and easy-to-use experimental platform for optogenetic neuromodulation,proving that the photostimulation therapy method has a complete application basis in the medical field and shows great market prospects.