Concentrations Of Per- And Polyfluoroalkyl Substances (PFASs) In The Blood Of Police Dogs And Associations With Blood Parameters

Per-and polyfluoroalkyl substances(PFASs)are persistent organic pollutants(POPs)that affected immune response with liver toxicity,reproductive toxicity,and were widely used in industrial production and daily life because of their chemical stability,hydrophobicity and thermal stability,for example,as fireproofing materials and lubricants.Exposure to PFASs has been reported in wildlife and humans,such as the northeastern tiger,golden monkey,and giant panda,but little has been reported about their exposure in dogs.In particular,the relationship between PFASs and hematological parameters in dogs is poorly understood.Perfluorooctanoate(PFOA)was found to be the dominant PFAS component in the blood(54.23%),followed by perfluorobutyric acid(PFBA)(16.05%)and perfluorooctanesulfonate(PFOS)(12.05%).On average,PFASs concentration in dogs was 3.553 ng/mL.Moreover,age is a key factor influencing levels of PFBA,PFOA,and PFBS in males,as well as seven PFASs(6:2 Cl-PFESA,PFBA,PFOA,PFOS,PFHx S,PFDA,and PFNA)in female dogs’ blood.The results revealed that PFHx S in dietary food accounted for most of the total daily PFASs consumption.We also discovered that greater PFASs exposure(PFOA and PFOS)significantly increased amylase(AMY)and decreased cholesterol(CHOL)levels.Furthermore,there are linear relationships between PFDA,PFNA and many biochemical parameters(AMY,CHOL,albumin/globulin(A/G),blood urea nitrogen(BUN),alkaline phosphatase(ALP),creatinine(CREA)).Thus,PFASs accumulation has a certain influence on dogs’ health,and we must pay attention to the potential threat these elements pose to dogs.