Remote Ischemic Preconditioning Provides Cardio Protection In Patients Received Percutaneous Coronary Intervention

Objective:The aim of the current study was to assess the myocardial protective effect of remote ischemic preconditioning(RIPC)on patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods:100 patients with CHD undergoing PCI were randomly divided into two groups:RIPC group 50 patients and control group 50 patients.Unilateral upper limb ischemic preconditioning was performed in the RIPC group with 24 hours before PCI.The levels of cardiac troponin I(cTnI),creatine kinase(CK),creatine kinase MB(CK-MB),serum creatine(Scr)and high sensitive C-reactive protein(hs-CRP)were compared before and after PCI procedure.Assess the impact on long-term major adverse cardiac events.Results:1.Comparison of general clinical data:There was no statistical difference between the two groups of patients in terms of age,gender,smoking history,history of hypertension and diabetes,BMI,LVEF,angina pectoris CCS grade,and use of drugs(P>0.05).2.Comparison of PCI data:There was no significant difference between the the two groups in the diseased blood vessels,the lesion type,the time and number of balloon dilatation,the diameter,as well as length and number of stents(P>0.05).The intraoperative chest pain and the ratio of ST segment shift>1mm were lower in the RIPC group than in the control group,and the difference was statistically significant(P<0.05).3.Comparison of biochemical examination results before and after PCI:There was not statistical difference between the RIPC group and the control group in the level of cTnI,CK,CK-MB,Scr and hs-CRP before PCI(P>0.05).The increase of cTnI,CK and CK-MB in the RIPC group was lower than that of the control group within 24 hours after operation(P<0.05),and the difference is statistically significant.However,the results of Scr and hs-CRP within 24 hours after operation were not statistically different(P>0.05).4.The incidence of major adverse cardiac events(MACE)six months after PCI was lower in the RIPC group than in the control group,the difference is statistically significant(P<0.05).Conclusion:RIPC can reduce PCI-related myocardial damage and improve clinical prognosis.It is a safe,effective and clinically feasible myocardial protection measure.