| Objective: This study aimed to investigate the role and clinical significance of red blood cell volume distribution width(RDW)in adult Still disease(AOSD)patients.Methods: Retrospectively analyzed the clinical data of 101 AOSD patients,who was the first hospitalized patients with clinical diagnosis and complete data of AOSD in the First Affiliated Hospital of Guangxi Medical University from January 2012 to April 2020.The AOSD patients were selected as the case group and the healthy people as the healthy control group.According to RDW level,they were divided into elevated RDW group(W)and normal RDW group(nRDW).Modified Pouchot score(Rau’s score)was used to evaluate the AOSD disease activity.According to Rau’s score level,patients were divided into active AOSD(aAOSD)and inactive AOSD(iAOSD).According to the course of disease from onset to initial visit,the patients were divided into group A,B and C(the course of disease ≤1 month was group A,< 1 month the course of disease≤3 months was group B,and the course of disease > 3 months was group C).According to the duration of treatment,they were divided into D,E and F groups(duration of treatment ≤1m was D group;1m < treatment duration ≤3m was Group E;treatment duration > 3m was Group F);According to the disease evolution of the patients,they were divided into good prognosis group(monocyclic disease)and poor prognosis group(polycyclic,chronic articular disease,).The differences of RDW in different groups were compared,and the correlation betweenRDW and disease activity and inflammatory indexes of AOSD was analyzed.All data were analyzed using SPSS26.0.Results: 1.The incidence of fever,pharynx pain,arthritis/arthralgia,and rash was from high to low in AOSD patients.Compared with healthy control group,RDW,peripheral white blood cell counts(WBC),lactate dehydrogenase(LDH),neutrophil/lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)in AOSD group were all increased(P < 0.01).2.The duration of disease in the W group was longer than that in the nRDW group.Hb and MCV were smaller than that in the nRDW group(P =0.000).There were no significant differences in the incidence of clinical manifestations,Rau’s score,WBC,hs-CRP,ESR and SF between W group and nRDW group(P > 0.05).3.There was no statistical difference inRDW between aAOSD and iAOSD groups.4.After treatment,WBC,hs-CRP,ESR and SF of AOSD patients decreased compared with those before treatment(P < 0.05),whilW increased after treatment(P < 0.05).5.ThW values of group A,B and C showed statistically significant differences(P < 0.01).ThW values of group C were the largest and the differences were statistically significant compared group A and B,while there was no statistically significant difference between group A and B.6.ThW values of D,E and F groups were statistically different(P <0.05).ThW values of F group were the smallest and the differences were statistically significant compared with D and E,while there was no statistically significant difference between D and E.7.RDW was positively correlated with duration of disease(P=< 0.05),had no significant correlation with heat peak,Rau’s score,WBC,hs-CRP,ESR and SF levels(P > 0.05).8.The heat peak value in the good prognosis group was higher than that in the poor prognosis group.The incidence of arthritis/joint pain was higher in the poor prognosis group(P < 0.05).There were no statistical differences in Rau’s score,RDW,hs-CRP,ESR and SF between the two groups(P > 0.05).AOSD good prognosis was statistically correlated with heat peak value(P < 0.05)and no statistical correlation between AOSD prognosis and Rau’s score,RDW,hs-CRP,ESR and SF(P > 0.05).Conclusion: 1.The level of RDW in AOSD patients was significantly higher than that in healthy people;2.RDW level was positively correlated with the duration of primary AOSD;3.RDW level had no significant correlation with AOSD disease activity,and had no significant correlation with serum hs-CRP,ESR and SF;4.RDW level has no significant significance in determining the type of AOSD disease evolution. |
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