| Objective: To evaluate the efficacy of Mongolian medicine Erdun-Urzil in the treatment of ischemic stroke by using functional magnetic resonance imaging(ASL),and to provide theoretical support for clinical application of this medicine.Methods: A total of 60 patients admitted to the Department of Mongolian Encephalopathy,Affiliated Hospital of Inner Mongolia University for Nationalities from December 2019 to December 2021 and diagnosed as acute ischemic stroke were screened,and randomly divided into control group and treatment group(30 patients in Erdun-Wuzhile group).The control group was treated according to the routine treatment of ischemic stroke,while the treatment group was treated with Mongolian medicine Erdun-Urzil on the basis of the routine treatment.Images of selected patients were collected before and after treatment.The changes of perfusion parameters in the affected side and the focal mirror area were analyzed before and after treatment.Results: The patients were 60.17±9.14 years old,with 34 males(56.67%)and 26 females(43.33%).In the control group,NIHSS score decreased from 12.15±1.81 to 7.65±1.63 and Mongolian syndrome score decreased from 23.29±1.93 to 12.19±0.73 before and after treatment.The CBF of the healthy side increased from 38.48±4.86ml/(100g.min)to40.57±4.98ml/(100g.min),and that of the affected side increased from 27.55±4.44ml/(100g.min)to 32.12±3.37ml/(100g.min).Before and after treatment,NIHSS score decreased from 12.00±1.93 to 6.83±1.39,and Mongolian syndrome score decreased from23.33±1.81 to 11.13±1.80.The CBF of the healthy side increased from 40.12±4.36ml/(100g.min)to 43.48±4.55ml/(100g.min),and that of the affected side increased from27.43±5.05ml/(100g.min)to 38.08±5.28ml/(100g.min).Statistical analysis showed that NIHSS score,Mongolian medicine symptom score,affected side and healthy side value of CBF in the control group were significantly different before and after treatment(P < 0.05).There were significant differences in NIHSS score,Mongolian medicine symptom score,affected side and healthy side of CBF in treatment group before and after treatment(P <0.05).The results showed that conventional treatment and conventional treatment + Erdun-Urzile treatment group were effective.NIHSS score after treatment and Mongolian medicine syndrome score after treatment were significantly different between the control group and the treatment group(P < 0.05).The results showed that the conventional treatment combined with Erdun-Urziele was more effective than conventional treatment.There was significant difference between the control group and the treatment group in CBF difference after treatment(P < 0.05).It indicates that Erdun-Urzil Mongolian medicine can increase the healthy side blood perfusion on the basis of anticoagulation,dilatation and vascularization therapy.There was significant difference between the control group and the treatment group in the difference between the affected side and the affected side of CBF after treatment(P < 0.05).These results indicated that erdun-Uzzielle could increase blood perfusion of affected side on the basis of conventional treatment.Conclusion:1.ASL technique can be used to evaluate the effect of drug therapy in ischemic stroke patients and provide the basis for imaging diagnosis.2.The greatest advantages of ASL in ischemic stroke patients are non-invasive and non-ionizing radiation,high repeatability,and high accuracy in measuring CBF.3.Erdun-uril can improve the cerebral blood flow,increase cerebral perfusion,improve the symptoms and prognosis of neurological deficit. |
PDF Full Text Request