Clinical Study On The Treatment Of Diarrhea Type Irritable Bowel Syndrome (Evidence Of Spleen-kidney-yang Deficiency) By Warming The Spleen And Kidney And Draining The Liver Formula Combined With Yiyang Cup Therapy

Objective: The purpose of this study was to evaluate the clinical efficacy of warming the spleen and kidney and draining the liver formula combined with Yiyang cup therapy in the treatment of diarrhea-type irritable bowel syndrome(IBS-D)with deficiency of spleen and kidney yang,and to explore the traditional Chinese medicine of warming the spleen and kidney and draining the liver formula combined with Yiyang cup therapy in the treatment of IBS-D.mechanism.Methods: The 93 cases of IBS-D patients with spleen and kidney yang deficiency syndrome included in this study were divided into treatment group,traditional Chinese medicine group and western medicine group according to computer random coding,31 cases in each group.The patients in the western medicine group were treated with Pinaverium Bromide Tablets.The course of treatment was 4 weeks,and the follow-up was 4 weeks.The clinical symptoms of patients with IBS-D were evaluated by TCM syndrome score scale and IBS symptom severity scale(IBS-SSS),and the patients with IBS-D were evaluated by self-rating anxiety scale and self-rating depression scale.Anxiety and depression state,evaluate the long-term curative effect by the recurrence rate,and observe the effect of warming the spleen and kidney and draining the liver formula combined with Yiyang cup therapy on Rendu two meridians,flank area,large abdomen area,waist area,liver area,and liver in IBS-D patients with spleen and kidney yang deficiency syndrome.The influence of the skin temperature of Shu points,Pishu points,Shenshu points,Taichong points and Taixi points,so as to reveal the TCM mechanism of their treatment of IBS-D.All data were analyzed using SPSS 26.0 statistical software.Results:1.Comparison of comprehensive clinical efficacy: the total effective rate of the treatment group was 93.1%,the total effective rate of the traditional Chinese medicine group was 80.6%,and the total effective rate of the western medicine group was 62.1%.The curative effect of the treatment group was significant.2.Comparison of TCM syndrome points: the total TCM syndrome points of all three groups improved compared with those before treatment(P<0.05)and the TCM syndrome efficacy of the treatment group was better than that of the Chinese medicine group and the Western medicine group(P<0.05),and the TCM syndrome efficacy of the Chinese medicine group was better than that of the Western medicine group(P<0.05),and the treatment group was more significant in improving the fear of cold extremities,lumbar and knee weakness,and intestinal tinnitus and yagging(P<0.05).3.Overall symptom comparison: the total IBS-SSS score decreased in all groups after treatment(P<0.05)and the overall efficacy of the treatment group was better than that of the Chinese medicine group and the western medicine group(P<0.05),and the overall efficacy of the Chinese medicine group was better than that of the western medicine group(P<0.05).All three groups improved the degree of abdominal pain,frequency of abdominal pain as well as stool satisfaction and life satisfaction after treatment(P<0.05),and the treatment group was more significant in improving the degree of abdominal pain,frequency of abdominal pain and degree of abdominal distension(P<0.05).4.Mental and psychological comparison: IBS patients were accompanied by anxiety in 35 patients(39.3%),depression in 12 patients(13.5%),and anxiety and depression in 10 patients(11.2%).The degree of anxiety and depression was mainly mild to moderate.All three groups could improve anxiety and depression(P<0.05),the treatment group had the same effect as the Chinese medicine group in improving anxiety and depression(P>0.05),and the treatment group and Chinese medicine group improved anxiety and depression better than the western medicine group(P>0.05).5.Comparison of infrared skin temperature: After 4 weeks of treatment,the treatment group could effectively improve the average temperature of the Du meridian,the large abdomen area,the waist area,the Ganshu,Pishu,Shenshu,Taichong and Taixi,and reduce the skin temperature of the flank area and Renmai(P< 0.05),in the traditional Chinese medicine group,the skin temperature of Rendu Ermai,waist area,Ganshu,Pishu,Shenshu,Taichong,and Taixi all increased,while the skin temperature of the flank area and big abdomen area decreased(P<0.05).Compared with the traditional Chinese medicine group,the skin temperature of Ganshu,Pishu,Taichong,Taixi and the skin temperature of the chest and flank area were significantly increased in the group(P<0.05).Statistical difference(P>0.05).6.Comparison of long-term efficacy: after 4 weeks of drug withdrawal,the recurrence rate of the treatment group was 11.1%,the recurrence rate of the Chinese medicine group was 19.2%,and the recurrence rate of the western medicine group was 57.9%.There was no statistical significance between the treatment group and the Chinese medicine group(P>0.05),the long-term efficacy of the treatment group and the traditional Chinese medicine group was better than that of the western medicine group(P<0.05).7.Safety comparison: There were no adverse reactions in the three groups of patients during the treatment,and the safety was good.Conclusion(s):1.The clinical efficacy of warming the spleen and kidney and draining the liver formula combined with Yiyang cup therapy in the treatment of IBS-D with spleen and kidney yang deficiency syndrome is better than that of the traditional Chinese medicine group and the western medicine group.In addition,the combination of warming the spleen and kidney and draining the liver formula combined with Yiyang cup therapy can improve IBS-D with spleen and kidney yang deficiency syndrome.Patients with anxiety and depression state,improve quality of life,reduce disease recurrence,safety and no obvious side effects,it is worthy of popularization and application.2.Warming and tonifying the spleen and kidney and soothing the liver combined with Yiyang cup therapy can increase the skin temperature of the Du meridian,large abdomen area,waist area,Pishu,Shenshu,Taichong and Taixi in IBS-D patients with spleen-kidney yang deficiency syndrome,lower the skin temperature of Ren meridian,The skin temperature in the flank area can unblock the Ren and Du meridians and the qi of the liver,spleen and kidney meridians,and regulate the qi mechanisms of the liver,spleen and kidney,so that the spleen yang rises,the kidney yang hides,and the wood stagnation disperses.It may be the TCM mechanism of treating IBS-D with spleen-kidney yang deficiency syndrome.