Analysis Of Drinking Characteristics And Clinical Characteristics Of Patients With Chronic Alcoholic Encephalopathy

Objective: Long-term drinking can cause irreversible damage to the structure and function of the nervous system.Early intervention of alcohol intake is the most important means to reduce neurological complications caused by chronic alcoholism.The purpose of this study was to explore the relationship between initial drinking age,drinking dose,drinking time and clinical symptoms and laboratory examination in patients with chronic alcoholic encephalopathy,so as to provide basis for the prevention of the disease.Methods: To screen male patients with complete clinical data who were first diagnosed as chronic alcoholic encephalopathy in the affiliated Hospital of Zunyi Medical University from January 2018 to December 2020.Collect demographic information,first visit time,clinical symptoms at admission,laboratory examination,as well as initial drinking age,alcohol consumption,drinking time and other related information.To analyze the basic characteristics,drinking characteristics and clinical manifestation types of different drinkers,and the relationship between drinking characteristics and the age of first medical treatment and laboratory examination.Results:(1)113 subjects were included,aged from 32 to 79 years old,with an average of 52.9 ±9.2years old.On admission,the main manifestations were mental and behavioral abnormalities in 28 cases(24.8%),cognitive impairment in 15 cases(13.3%),seizures in 7 cases(6.2%),dyskinesia in 4 cases(3.5%)and disturbance of consciousness in 4 cases(3.5%).55 cases(48.7%)had more than two kinds of symptoms.(2)abnormal mental behavior was the main manifestation in the initial drinking age < 18 years old group and 18-30 years old group,and cognitive dysfunction was the main manifestation in the > 30 years old group.(3)Clinical symptoms appeared after 31.42 ±10.14 years in the group of initial drinking age < 18 years,25.92 ±6.96 years after 25.92 ±6.96 years in the group of 18-30 years old,and21.33 ±9.9 years later in the group of > 30 years old.there was significant difference between the > 30 years group and the other two groups(P < 0.05).(4)the average daily alcohol consumption of 50-125 g,125-250 g and > 250 g had no significant effect on the onset time of chronic alcoholic encephalopathy,and there was no significant difference among the three groups(P > 0.05).(5)the levels of aspartate aminotransferase and alanine aminotransferase in the drinking time > 30 years group were significantly higher than those in the other two groups(P < 0.05),but there was no significant difference between the other two groups.Conclusion: Men who consumed more than 50 g of alcohol a day were considered unsafe,and the higher the average daily alcohol intake,the more likely they were to have more than two clinical symptoms at the first visit.Drinking after the age of 30 is easy to lead to liver function and other organ function damage,and more likely to occur in a short period of time chronic alcoholic encephalopathy.