Clinical Observation On The Combined Application Of The YunZhongGuShen Method In The Early Treatment Of Hepatocellular Carcinoma Cachexia

Objective:A randomized open study design,through controlled clinical trials,assessment is solid renal transport method to improve the middle-late early in patients with liver cancer cachexia appetite,the curative effect of clinical symptoms and quality of life,observation of solid renal method in safety,preliminary explore the clinical application value,provide new train of thought of TCM diagnosis and treatment for terminal-stage liver cancer cachexia.Methods:Using the method of random number table,58 patients with advanced hepatocellular carcinoma(HCC)were randomly divided into two groups: treatment group(30 cases)and control group(28 cases).FAACT scale score(physiological status,functional status,additional concerns,etc.),PG-SGA scale score(weight change,diet,physical condition and symptoms,physical examination,etc.),KPS score,serum albumin and other changes in the two groups were observed and recorded before treatment and at the 4th week of treatment.Results:(1)Comparison of KPS score: there was no significant difference in KPS score between the two groups after treatment,and there was significant difference in THE control group before and after treatment,with statistical significance(P < 0.05);The experimental group also had statistical significance before and after treatment(P <0.01),and the difference was more significant.(2)Comparison of FAACT scale-physiological status score: the physiological status score of the experimental group(20.05±2.86)was significantly higher than that of the control group(17.83±2.91),and the difference was statistically significant(P < 0.05);(3)FAACT scale-functional status score comparison: there was no significant difference in functional status score between the experimental group(15.45±1.76 points)and the control group(14.5±1.38points)after treatment(P > 0.05 points).(4)Comparison of FAACT scale-additional concern score: after treatment,the additional concern score of the experimental group(28.05±3.58 points)was significantly higher than that of the control group(25.67±2.87 points),with statistical significance(P < 0.05);(5)Comparison of body weight changes: after treatment in the experimental group,19 cases(63.3%)had obvious effect,6 cases(20%)were stable,5 cases(16.7%)had no effect;In the control group,11 cases(39.3%)were markedly effective,11 cases(39.3%)stable and6 cases(21.4%)ineffective after treatment.There was no significant difference between the experimental group and the control group(P < 0.05).(6)Comparison of appetite changes: in the experimental group,appetite increased in 25 cases(83.3%),remained unchanged in 3 cases(10%)and decreased in 2 cases(6.7%)after treatment;In the control group,appetite increased in 16 cases(57.1%),remained unchanged in 8cases(28.6%)and decreased in 4 cases(14.3%)after treatment.After statistical analysis,there was a significant difference between the two groups(P < 0.05).The appetite improvement in the experimental group was better than that in the control group.(7)Comparison of subjective overall nutritional status(PG-SGA)score: After treatment,the subjective overall nutritional status score of the experimental group(28.05±3.58 points)was significantly higher than that of the control group(25.67±2.87 points),with statistical significance(P < 0.05);(8)Comparison of serum albumin level before and after treatment: there was no significant difference in serum albumin level between the experimental group(32.83±3.19g/L)and the control group(32.32±2.10g/L)(P < 0.05).(9)Comparison of safety evaluation: in the experimental group,nausea occurred in 8 cases(26.7%),vomiting in 4 cases(13.3%),thrombosis in 2 cases(6.7%),and lower limb edema in 10 cases(33.3%).In the control group,there were 11 cases of nausea(39.2%),6 cases of vomiting(21.4%),3 cases of thrombosis(10.7%)and 13 cases of lower limb edema(46.4%).Conclusions :(1)in terms of KPS score,FAACT scale-physiological status,additional concern part,appetite improvement,overall nutritional status and other aspects,the effect of megestrel acetate combined with kidney fixation was better than megestrel acetate alone;(2)In FAACT scale-functional status,body weight,serum albumin and other aspects,there was no significant difference between the combined use of medaprogesterone acetate and the kidney fixation method in transit and medaprogesterone acetate alone,which may be related to sample size and insufficient observation time.(3)The combined use of Traditional Chinese medicine can effectively reduce the incidence of adverse reactions in the treatment of patients with tumor cachexia to a certain extent.