Correlation Between Peripheral Blood Monocyte Subsets And Bone Injury And Tumour Load In Patients With Multiple Myeloma

Objective:To observe the expression of CD16⁺CD14⁺monocytes and CD16⁺CD14^dimmonocytes in peripheral blood of newly diagnosed patients with multiple myeloma and its correlation with clinical indicators such as bone injury and tumor load.Methods:A retrospective study was performed on 36 newly diagnosed multiple myeloma patients admitted to the Hematology Department of Shanxi Provincial People’s Hospital from September 2018 to March 2021.The expression of monocyte subsets in peripheral blood of patients with different clinicopathological characteristics was compared,and the correlation between the above indicators and bone damage and tumor load was analyzed.Results:1.The proportion of CD16⁺CD14⁺monocytes and CD16⁺CD14^dimmonocytes in peripheral blood of newly diagnosed MM patients was increased to varying degrees.2.There were significant differences in the expression of CD16⁺CD14⁺monocytes and CD16⁺CD14^dimmonocytes subsets among patients with different hemoglobin,β2 microglobulin,FISH and bone marrow plasma cell ratio.（all P<0.05）.3.Correlation analysis showed that the proportion of CD16⁺CD14⁺monocytes and CD16⁺CD14^dimmonocytes was positively correlated with the proportion of marrow plasma cells,lactate dehydrogenase level,Durie-Salmon stage,ISS stage and R-ISS stage.（P<0.05）.4.CD16⁺CD14⁺monocytes were positively correlated with serum corrected calcium,alkaline phosphatase and MBD bone disease grade（P<0.05）.Conclusion:In the peripheral blood of newly diagnosed MM patients,CD16⁺CD14⁺monocytes and CD16⁺CD14^dimmonocytes increased in varying degrees,and positively correlated with tumor load,and the proportion of CD16⁺CD14⁺monocytes was also related to the degree of bone destruction.These results suggest that monocyte subsets may be involved in the pathogenesis and development of multiple myeloma and reflect the prognosis to some extent.