Expression Of CD39/CD73 In Cervical Squamous Cell Carcinoma And Its Relationship With Disease Progression And Prognosis

Objective:To investigate the relationship between the expression of CD39/CD73 in cervical squamous cell carcinoma and disease progression and prognosis.Methods:Immunohistochemistry was used to detect the expression of CD39/CD73 in 23cervicitis,21 LSIL,25 HSIL and 131 CSCC tissue samples.The degree of staining of expression was calculated semiquantitatively,and its relationship with clinicopathological parameters and prognosis in the CSCC group was analyzed by SPSS.Results:1.CD39/CD73 was mainly expressed in the cytoplasm,capsule,and stromal vascular endothelial cells of lesion/tumor epithelial cells,and the expression of CD39 in the cervicitis,LSIL,HSIL,and CSCC groups gradually decreased with the severity of the lesion;CD73 gradually increased.2.CD39 expression level was correlated with SCCA,FIGO stage,lymph node metastasis,lymphovascular space invasion,histological grade,and survival status;CD73expression was correlated with FIGO stage,HR-HPV,positive lymph node metastasis,positive lymphovascular space,and survival status（p<0.05）;and CD39 and CD73expression were negatively correlated.3.Univariate and multivariate Cox regression analysis showed that CSCC patients with high CD73 expression,positive lymph node metastasis,and FIGO stage（stage II）in tumor tissues had an increased risk of death,suggesting that CD73 can be an independent predictor of poor prognosis in CSCC patients.4.Patient survival was lowest in the CD73^highCD39^low group and highest in the CD73^low CD39 ^high group.Conclusion:1.In cervical squamous cell carcinoma,CD39 expression is low and CD73 expression is high with increasing stage,suggesting that its immunosuppressive effect is involved in the occurrence and development of cervical squamous cell carcinoma;2.Combined detection of CD39 and CD73 provides a clinical reference for judging the prognosis of cervical squamous cell carcinoma.