Predictive Value Of Peripheral Blood Neutrophil-to-Lymphocyte Ratio And Immunoglobulin IgG Expression For Prognosis Of Young Breast Cancer

Objective:In the past ten years,studies have shown that NLR is closely related to the prognosis of breast cancer.In this paper,a statistical analysis was conducted on the relationship between neutrophil and lymphocyte ratio(NLR)and the prognostic factors of young breast cancer,in order to improve the prognosis of breast cancer patients.And the choice of treatment plan provides a certain reference value.Methods:We retrospectively collected and analyzed 127 young breast cancer patients(all<40 years old)admitted to the Breast Surgery Department of Gui Zhong Medical University Affiliated Hospital from October 2013 to December 2016.The independent prognostic factors were analyzed using univariate and multivariate Cox proportional hazards regression models.Postoperative DFS,OS and survival curves were compared using Kaplan-Meier and log-rank tests.Results:In the statistical 127 young breast cancer patients,the ROC curve was used to divide the NLR into two groups;in the patients with NLR<2.62 group,the postoperative follow-up found that the DFS was 46.71 months,and the median OS was 58.91 months.In the NLR≥2.62 group,the median postoperative DFS was36.13 months,and the median overall survival time was 53.27 months.The postoperative disease-free survival and overall survival time in the NLR<2.62 group were higher than those in the NLR≥2.62 high group.the differences in survival indicators such as DFS and OS time between the two groups were statistically significant.The median value of immunoglobulin Ig G in subgroup analysis was11.5g/L;in the Ig G <11.5 group,the postoperative disease-free survival and overall survival time of patients in the NLR<2.62 group were higher than NLR For patients in the ≥2.62 group,the difference in DFS and OS survival time between the two groups was statistically significant(P<0.05);in the patient group with Ig G ≥11.5,the postoperative disease-free survival and overall survival time of the patients in the NLR<2.62 group were both significantly higher(P < 0.05).For patients with NLR≥2.62,the difference in DFS of disease-free survival between the two groups was statistically significant(P<0.05),and the difference in overall survival time between the two groups was not statistically significant(P>0.05).Conclusions:NLR may be one of the independent prognostic indicators of young breast cancer.Young breast cancer patients with lower NLR ratio and lower expression of immunoglobulin Ig G have longer postoperative disease-free survival,lower recurrence rate and better prognosis better.