Effects Of Mongolian Medicine Eerdun Wurile On Postoperative Cognitive Function And Serum BDNF In Elderly Patients

Objective By applying Mongolian medicine Eerdun Wurile to elderly patients undergoing thoracoscopic lobectomy surgery,the effects of Eerdun Wurile on postoperative cognitive function and the changes of serum levels of related factors represented by BDNF were observed,providing clinical evidence for the prevention and treatment of postoperative cognitive dysfunction.Methods Sixty elderly patients who underwent thoracoscopic lobectomy under general anesthesia were randomly assigned to the experimental group（group T,n=30）and the control group（group C,n=30）by random number table method.In the experimental group,Eerdun Wurile was taken 3 days before surgery for a total of 7 days（15 capsules per day）.The control group received placebo for the same time.The patient’s heart rate,non-invasive blood pressure and blood oxygen saturation were recorded 3 days before medication（T₁）,24h after surgery（T₂）and 72h after surgery（T₃）,as well as VAS pain scores at T₂and T₃time points after surgery.5ml of venous blood was drawn at three time points:three days before the operation（T₁）,24h after the operation（T₂）,and 72h after the operation（T₃）.Enzyme-linked immunoassay was used to detect BDNF、TNF-α、IL-1βand Tau protein levels.Mini-mental State Examination was used to evaluate cognitive function of the patients at the time points:T₁and 5 days after the operation（T₄）.Results Compared with T₁within the group,the serum level of BDNF in group C and group T at postoperative T₂and T₃was decreased,the difference was statistically significant（P<0.05）.Compared with group C,the decrease of serum BDNF level at T₂and T₃in group T was smaller,and the difference was statistically significant（P<0.05）Compared with T₁within the group,the serum levels of inflammatory factors TNF-α,IL-1βand Tau protein in 2 groups showed an increasing trend at postoperative T₂and T₃time points,with statistical significance（P<0.05）.Compared with group C,the levels of inflammatory factors TNF-α,IL-1βand Tau protein in serum of group T at T₂and T₃increased less,and the differences were statistically significant（P<0.05）.Compared with T₁within the group,MMSE score at T₄time point after surgery was decreased in both groups,with statistically significant difference（P<0.05）.Compared with group C,MMSE score at postoperative T₄time point in group T was higher,and the difference was statistically significant（P<0.05）.Conclusion Mongolian medicine Eerdun Wurile can reduce the incidence of postoperative cognitive dysfunction in elderly patients.Preoperative administration of Mongolian medicine Eerdun Wurile can reduce the decrease of serum BDNF concentration,and play an important neuroprotective role in inhibiting neuronal cell apoptosis and promoting nerve cell repair and regeneration.