Preparation And Mineralization Properties Of Bioactive Glass For Mandibular Bone Repair Materials

Objective To study the effect of different contents of P₂O₅and B₂O₃replacing SiO₂on the mechanical intensity and biological function of bioactive glass,to furnish a theoretical foundation for ensuing biomaterials in cell and animal tentatives and product development.Methods The base glass with different compositions was fired by high temperature melting method,and the porous bioactive glass scaffold was fabricated by organic foam impregnation method.Mechanical properties were tested using uniaxial compression and three-point bending methods on a universal mechanical testing machine.The biological function of the tested materials:Calculate the percentage of mass loss after soaking in standard simulated body fluid（SBF）compared with before soaking,observe the morphology change of the sample surface after soaking by scanning electron microscope（SEM）and X-ray diffraction analysis（XRD）after soaking the phase composition of the sample.Results（1）There were statistically significant differences in the compressive strength and flexural strength of the five groups of porous scaffolds A,B,C,D,and E（P=0.00<0.05）.Using the post-hoc Least-Significant Difference（LSD）multiple comparison method,it was found that there was no significant difference between group A and group B（P>0.05）,and there were statistical differences between the other groups（P<0.05）.（2）After soaking for 1day in A,B,C,D,and E,there was a statistically significant difference in the percentage of mass loss of porous scaffolds among the five groups（P=0.00<0.05）.Post hoc multiple comparisons were performed using the LSD method,it was found that the percentage of mass loss among groups A,B,and C was not statistically significant,the percentage of mass loss between groups C and D was not statistically significant,and the mass loss among the other groups was not statistically significant.The percentages were all statistically significant（P<0.05）.After immersion for 3d and 7d,there was a statistically significant difference in the percentage of mass loss of porous scaffolds among the five groups（P=0.00<0.05）.The LSD method was used to compare the groups afterwards,and it was found that there was no significant difference in the percentage of mass loss between groups A and B（P>0.05）,and the percentages of mass loss between the other groups were statistically significant（P<0.05）.（3）After soaking in SBF,it was detected by SEM and XRD that groups A and B had no in vitro mineralization activity,while groups C,D,and E had mineralization activity and gradually increased.（4）There were statistically significant differences in the compressive strength and flexural strength of the porous scaffolds among the four groups E,E1,E2,and E3（P=0.00<0.05）,and the LSD comparison after the event showed that there were statistical differences among the comparison groups（P=0.00<0.05）.（5）After E,E1,E2,E3 soaked for 1d,3d and 7d,the difference in the percentage of mass loss of porous scaffolds among the four groups was statistically significant（P=0.00<0.05）.Further LSD multiple comparisons showed that the percentage of mass loss between each group was statistically significant（P<0.05）.（6）After soaking in SBF,it was found that E,E1,E2,and E3 groups all had mineralization activity,and it gradually increased.Conclusion（1）Both P₂O₅and B₂O₃replacing SiO₂could enhance the mechanical properties of porous bioactive glass scaffolds,but the scaffolds could not be formed when the P₂O₅content reached 12 wt%.（2）P₂O₅and B₂O₃substitute SiO₂can significantly promote the solution performance and in vitro mineralization function of glass.