Study On The Association Between Psychological Status During Pregnacy And Glucolipid Metabolism And Pregnancy Outcome

Background:In recent years,maternal psychological problems during pregnancy have been gradually becoming a major public health problem.At the outline of the "The Plan of Healthy China 2030" and other documents,the Chinese government has required to strengthen the management of maternal psychological health during pregnancy.The expert consensus on screening and diagnosis and treatment of perinatal depression in 2021 points out that perinatal depression may cause adverse effects on mother,fetus and newborn.It is recommended that pregnant women should be screened one time at least,and early pregnancy is a reasonable screening time.In 2019,the expert consensus on maternal mental health management proposed that the time range of maternal mental health management mainly includes the period from pregnancy preparation to one year after deliveryed.Studies have shown that gestational diabetes is associated with depression.Depression increases the risk of progressive insulin resistance and type 2 diabetes.The disorder of hypothalamic pituitary adrenal(HPA)axis is the key link for the coexistence of depression and diabetes.Previous studies on prenatal anxiety were relatively few,and the results of studies on depression and anxiety during pregnancy,glucolipid metabolism and pregnancy outcomes were inconsistent.The purpose of this study is to explore the influencing factors of depression and anxiety during pregnancy and the correlation with glucolipid metabolism and adverse pregnancy outcomes,so as to identify high-risk factors early,prevent and intervene in time,reduce the incidence of depression and anxiety during pregnancy and improve adverse pregnancy outcomes.Objective:To analyze the maternal depression and anxiety during pregnant and analyze the related factors;To explore the association between gestational depression,anxiety and glucolipid metabolism,adverse pregnancy outcomes,so as to provide scientific theoretical basis for targeted perinatal psychological monitoring and intervention.Methods:We selected the pregnant women who were registered in the outpatient department of Guangzhou Haizhu District Maternal and Child Health Hospital from March 2022 to July 2022 for prenatal examination and hospitalization as the research objects by convenience sampling method.The pregnant women in the outpatient department were screened through the self-made general situation questionnaire and the Edinburgh Postpartum Depression Scale(EPDS).The pregnant women in the hospital were additionally screened by General Anxiety Disorder 7(GAD-7).To analyze the influencing factors of depression and anxiety during pregnancy.To analyze the association between gestational depression,anxiety and glucolipid metabolism,adverse pregnancy outcomes.Results:1.The prevalence of gestational depression was 35.0%(the prevalence of mild depression was 23.3%,the prevalence of moderate and severe depression was 11.7%).The prevalence of gestational anxiety was 28.4%(the prevalence of mild anxiety was 25.9%,the prevalence of moderate and severe anxiety was 2.5%).2.The influencing factors of pregnancy depression included:pre-pregnancy body mass index(<18.5 kg/m2 OR=1.508),diet structure(OR=2.034),annual family income(income<80000 yuan OR=2.034),relationship with elders(OR=3.153),sleep status(unsatisfactory OR=5.657,general OR=1.788),family history(OR=1.657),all P<0.05.The influencing factors of anxiety during pregnancy included parity(OR=2.205),dietary structure(OR=3.104),sleep status(unsatisfactory OR=7.601,general OR=2.131),all P<0.05.There was a strong positive correlation between depression and anxiety during pregnancy,R=0.656(P<0.001).3.There was no significant difference between the level of glucolipid metabolism in GDM pregnant women and non GDM pregnant women and their pregnancy depression and anxiety(P>0.05).The incidence of neonatal hypoglycemia with gestational depression was higher than those without depression(P<0.05).There was no significant difference between pregnancy anxiety and adverse pregnancy outcomes(P>0.05).Conclusion:1.The prevalence of gestational depression and anxiety is high.2.Low pre-pregnancy body mass index,unbalanced diet structure,low annual family income,inharmonious relationship with elds,sleep disorder and family history are all risk factors of depression during pregnancy.Primiparity,unbalanced diet structure and sleep disorder are all risk factors of anxiety during pregnancy.Gestational depression was positively correlated with gestational anxiety.3.Gestational depression and anxiety have no significant correlation on glucolipid metabolism.Depression during pregnancy increases the incidence of neonatal hypoglycemia.There is no association between gestational depression and other adverse pregnancy outcomes.There is no association between gestational anxiety and adverse pregnancy outcomes.